二氢白屈菜红碱 A-E，新型细胞松弛素类化合物，来自于沉香内生真菌 Diaporthe sp. BMX12 的分离。
Diaporchalasins A-E, New Cytochalasins from the Endophytic Fungus Diaporthe sp. BMX12 Isolated from Aquilaria sinensis.
机构信息
Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, 571101, China.
Sanya Nanfan Research Institute, Hainan University, Sanya, 572025, China.
出版信息
Chem Biodivers. 2024 Jun;21(6):e202400567. doi: 10.1002/cbdv.202400567. Epub 2024 May 9.
Five new cytochalasins, diaporchalasins A-E (1-5), together with 14 known congeners (6-19) were isolated from the endophytic fungus Diaporthe sp. BMX12, which was isolated from the branches of Aquilaria sinensis. The structures of the new compounds were elucidated by extensive spectroscopic analyses including high-resolution electron spray ionization mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR). Their absolute configurations were assigned by theoretical electronic circular dichroism (ECD) calculations. Compounds 11 and 12 featuring a keto carbonyl at C-21 displayed cytotoxicity toward K562, BEL-7402, SGC-7901, A549, and HeLa cell lines with IC values ranging from 4.4 to 47.4 μM.
五种新的细胞色素，即 diaporchalasins A-E（1-5），与 14 种已知的同系物（6-19）一起，从内生真菌 Diaporthe sp. BMX12 中分离出来，该真菌是从沉香的树枝中分离出来的。新化合物的结构通过广泛的光谱分析（包括高分辨电子喷雾电离质谱（HR-ESI-MS）和核磁共振（NMR））来阐明。它们的绝对构型通过理论电子圆二色性（ECD）计算来确定。具有 C-21 酮羰基的化合物 11 和 12 对 K562、BEL-7402、SGC-7901、A549 和 HeLa 细胞系表现出细胞毒性，IC 值范围为 4.4 到 47.4 μM。
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