School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China.
College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
Mar Drugs. 2024 Sep 5;22(9):407. doi: 10.3390/md22090407.
Twelve compounds, including four undescribed cytochalasins, xylariachalasins A-D (-), four undescribed polyketides (-), and four known cytochalasins (-), were isolated from the mangrove endophytic fungus QYF. Their structures and absolute configurations were established by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS), electronic circular dichroism (ECD) calculations, C NMR calculation and DP4+ analysis, single-crystal X-ray diffraction, and the modified Mosher ester method. Compounds and are rare cytochalasin hydroperoxides. In bioactivity assays, Compound exhibited moderate antimicrobial activities against and with MIC values of 12.5 μM for both Compound exhibited significant cytotoxic activity against MDA-MB-435 with an IC value of 3.61 ± 1.60 μM.
从红树林内生真菌 QYF 中分离得到了 12 种化合物，包括 4 种新的细胞松弛素，即 xylariachalasins A-D(-)，4 种新的聚酮类化合物(-)和 4 种已知的细胞松弛素(-)。通过广泛的光谱分析(1D 和 2D NMR、HRESIMS)、电子圆二色性(ECD)计算、C NMR 计算和 DP4+分析、单晶 X 射线衍射和改进的 Mosher 酯法确定了它们的结构和绝对构型。化合物和是罕见的细胞松弛素过氧化物。在生物活性测定中，化合物对和显示出中等的抗菌活性，MIC 值均为 12.5 μM。化合物对 MDA-MB-435 表现出显著的细胞毒性活性，IC 值为 3.61 ± 1.60 μM。
