School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan , Hubei 430074 , PR China.
Org Lett. 2019 Sep 6;21(17):6957-6960. doi: 10.1021/acs.orglett.9b02552. Epub 2019 Aug 12.
A cytochalasan, xylarichalasin A, was obtained from the endophytic fungus cf. harbored in . Its structure was elucidated by comprehensive spectroscopic methods including HRESIMS, 1D/2D NMR, and residual dipolar coupling analysis as well as quantum chemistry calculations including DFT GIAO C NMR and ECD calculation. It has an unprecedented 6/7/5/6/6/6 fused polycyclic structure. In bioassay, xylarichalasin A showed cytotoxicity against human cancer cell lines with IC value ranging from 6.3-17.3 μM.
一种细胞松弛素，木藜芦醛 A，从内生真菌 cf. 中分离得到，该真菌寄生于 。其结构通过全面的光谱方法阐明，包括高分辨率质谱，1D/2D NMR 和残基偶极耦合分析以及量子化学计算，包括 DFT GIAO C NMR 和 ECD 计算。它具有前所未有的 6/7/5/6/6/6 稠合多环结构。在生物测定中，木藜芦醛 A 对人癌细胞系表现出细胞毒性，IC 值范围为 6.3-17.3 μM。
