罗塞利查斯因 A-H，来自内生真菌罗赛利尼菌 Glinf021 的细胞毒细胞色素。
Rosellichalasins A-H, cytotoxic cytochalasans from the endophytic fungus Rosellinia sp. Glinf021.
机构信息
Department of Plant Pathology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing, 100193, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100050, China.
出版信息
Phytochemistry. 2024 Jun;222:114103. doi: 10.1016/j.phytochem.2024.114103. Epub 2024 Apr 16.
Eight new cytochalasans rosellichalasins A-H (1-8), as well as two new shunt metabolites rosellinins A (9) and B (10) before intramolecular Diels-Alder cycloaddition reaction in cytochalasan biosynthesis, along with nine known cytochalsans (11-19) were isolated from the endophytic fungus Rosellinia sp. Glinf021, which was derived from the medicinal plant Glycyrrhiza inflata. Their structures were characterized by extensive analysis of 1D and 2D NMR as well as HRESIMS spectra and quantum chemical ECD calculations. The cytotoxic activities of these compounds were evaluated against four human cancer cell lines including HCT116, MDA-MB-231, BGC823, and PANC-1 with IC values ranging from 0.5 to 58.2 μM.
从药用植物胀果甘草内生真菌 Rosellinia sp. Glinf021 中分离得到 8 个新的细胞松弛素 rosellichalasins A-H（1-8），以及 2 个新的支路代谢产物 rosellinins A（9）和 B（10），它们在细胞松弛素生物合成中经历分子内 Diels-Alder 环加成反应之前。这些化合物与 9 种已知的细胞松弛素（11-19）一起被分离出来。通过对 1D 和 2D NMR 以及 HRESIMS 光谱和量子化学 ECD 计算的广泛分析，确定了它们的结构。这些化合物对包括 HCT116、MDA-MB-231、BGC823 和 PANC-1 在内的四种人癌细胞系的细胞毒性活性进行了评估，IC 值范围为 0.5 至 58.2 μM。
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