Tagawa M, Shibata J, Tomonaga M, Amenomori T, Yoshida Y, Kuriyama K, Matsuo T, Sadamori N, Ichimaru M
Br J Haematol. 1985 Jul;60(3):449-55. doi: 10.1111/j.1365-2141.1985.tb07442.x.
Complete remission was achieved in a case of hypoplastic acute myeloid leukaemia with chromosomal aberration of No. 8-trisomy by giving very low dose of cytosine arabinoside (ara-C), 10 mg (7 X 5 mg/m2)/d, by 24 h continuous intravenous infusion for 20 d. We observed a definite cytoreduction phase in the bone marrow (BM) before normal haematopoiesis resumed. The remission BM showed only normal karyotypes in all metaphases examined. Granulocyte/macrophage colonies and erythroid bursts recovered sufficiently in numbers and cytogenetic study on single colonies and bursts revealed only normal karyotypes. These observations provide evidence that a low dose ara-C regimen can induce remission by cytoreduction which diverts the growth advantage from the leukaemic clone to the normal clones.
通过给予极低剂量的阿糖胞苷（ara-C），即10毫克（7×5毫克/平方米）/天，持续24小时静脉输注20天，一名患有8三体染色体畸变的低增生性急性髓系白血病患者实现了完全缓解。在正常造血恢复之前，我们观察到骨髓中有明确的细胞减少期。缓解期骨髓在所有检查的中期仅显示正常核型。粒细胞/巨噬细胞集落和红系爆式集落数量充分恢复，对单个集落和爆式集落的细胞遗传学研究仅显示正常核型。这些观察结果提供了证据，表明低剂量阿糖胞苷方案可通过细胞减少诱导缓解，从而将生长优势从白血病克隆转移到正常克隆。
