Institute of Mechanobiology & Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang, Shanghai 200240, China; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China.
Institute of Mechanobiology & Medical Engineering, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang, Shanghai 200240, China.
Biomed Pharmacother. 2024 May;174:116545. doi: 10.1016/j.biopha.2024.116545. Epub 2024 Apr 10.
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Others and our studies have shown that mechanical stresses (forces) including shear stress and cyclic stretch, occur in various pathological conditions, play significant roles in the development and progression of CVDs. Mitochondria regulate the physiological processes of cardiac and vascular cells mainly through adenosine triphosphate (ATP) production, calcium flux and redox control while promote cell death through electron transport complex (ETC) related cellular stress response. Mounting evidence reveal that mechanical stress-induced mitochondrial dysfunction plays a vital role in the pathogenesis of many CVDs including heart failure and atherosclerosis. This review summarized mitochondrial functions in cardiovascular system under physiological mechanical stress and mitochondrial dysfunction under pathological mechanical stress in CVDs (graphical abstract). The study of mitochondrial dysfunction under mechanical stress can further our understanding of the underlying mechanisms, identify potential therapeutic targets, and aid the development of novel treatments of CVDs.
心血管疾病（CVDs）是全球范围内导致死亡的主要原因。其他人以及我们的研究表明，在各种病理条件下会发生机械应力（力），包括切应力和循环拉伸，这些机械应力在 CVDs 的发展和进展中起着重要作用。线粒体主要通过三磷酸腺苷（ATP）产生、钙通量和氧化还原控制来调节心脏和血管细胞的生理过程，同时通过电子传递复合物（ETC）相关的细胞应激反应促进细胞死亡。越来越多的证据表明，机械应激诱导的线粒体功能障碍在许多 CVDs 的发病机制中起着至关重要的作用，包括心力衰竭和动脉粥样硬化。本综述总结了生理机械应激下心血管系统中线粒体的功能以及 CVDs 中病理机械应激下的线粒体功能障碍（示意图）。对机械应激下的线粒体功能障碍的研究可以进一步了解潜在的机制，确定潜在的治疗靶点，并有助于开发 CVDs 的新治疗方法。
