Murgo A J
J Natl Cancer Inst. 1985 Aug;75(2):341-4.
The antitumor effect of methionine-enkephalin [( Met]enkephalin) was demonstrated in C57BL/6J mice inoculated with B16-BL6 melanoma cells. Local subcutaneous tumor growth was inhibited with a 50-micrograms dose daily for 7 or 14 days. The antitumor effect of [Met]enkephalin was inhibited by the administration of the opioid receptor antagonist naloxone. Naloxone alone had no significant effect on tumor growth.
在接种了B16 - BL6黑色素瘤细胞的C57BL/6J小鼠中证实了甲硫氨酸脑啡肽[（Met）脑啡肽]的抗肿瘤作用。每天给予50微克剂量，持续7天或14天，可抑制局部皮下肿瘤生长。阿片受体拮抗剂纳洛酮的给药可抑制[Met]脑啡肽的抗肿瘤作用。单独使用纳洛酮对肿瘤生长无显著影响。
