Faith R E, Murgo A J, Clinkscales C W, Plotnikoff N P
Ann N Y Acad Sci. 1987;496:137-45. doi: 10.1111/j.1749-6632.1987.tb35756.x.
Host resistance to disease is dependent upon a number of factors. Recent evidence indicates that natural killer (NK) cells play an important role in resistance to both neoplastic and virally induced disease. Treatment of C57Bl/6 mice with methionine-enkephalin (1, 3, 10, or 30 mg/kg body weight) results in significant increases in NK activity of splenic lymphocytes 20 hours after injection of the enkephalin. Enkephalin treatment also enhances host resistance. The short-term survival of A/J female mice after HSV-2 infection was significantly increased by daily subcutaneous injections (3 mg/kg body weight) of methionine-enkephalin. Similarly, daily doses of 50 micrograms of methionine-enkephalin for 7 to 14 days inhibit the local subcutaneous tumor growth of B15 melanoma in C57Bl/6 mice.
宿主对疾病的抵抗力取决于多种因素。最近的证据表明，自然杀伤（NK）细胞在抵抗肿瘤性疾病和病毒诱导的疾病中都起着重要作用。用甲硫氨酸脑啡肽（1、3、10或30毫克/千克体重）处理C57Bl/6小鼠，在注射脑啡肽20小时后，脾脏淋巴细胞的NK活性显著增加。脑啡肽处理还增强了宿主抵抗力。通过每天皮下注射（3毫克/千克体重）甲硫氨酸脑啡肽，可显著提高A/J雌性小鼠感染单纯疱疹病毒2型后的短期存活率。同样，每天给予50微克甲硫氨酸脑啡肽，持续7至14天，可抑制C57Bl/6小鼠中B15黑色素瘤的局部皮下肿瘤生长。
