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Nat Microbiol. 2020 Dec;5(12):1598-1607. doi: 10.1038/s41564-020-00813-8. Epub 2020 Oct 26.
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新冠病毒:如果免疫力下降会怎样?

COVID-19: What if immunity wanes?

作者信息

Çenesiz M Alper, Guimarães Luís

机构信息

Nottingham Trent University.

Queen's University Belfast and cef.up.

出版信息

Can J Econ. 2022 Feb;55(Suppl 1):626-664. doi: 10.1111/caje.12542. Epub 2022 Mar 3.

DOI:10.1111/caje.12542
PMID:38607901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9111512/
Abstract

Using a simple economic model in which social distancing reduces contagion, we study the implications of waning immunity for the epidemiological dynamics and social activity. If immunity wanes, we find that COVID-19 likely becomes endemic and that social distancing is here to stay until the discovery of a vaccine or cure. But waning immunity does not necessarily change optimal actions on the onset of the pandemic. Decentralized equilibria are virtually independent of waning immunity until close to peak infections. For centralized equilibria, the relevance of waning immunity decreases in the probability of finding a vaccine or cure, the costs of infection (e.g., infection-fatality rate), the degree of partial immunity and the presence of other NPIs that lower contagion (e.g., quarantining and mask use). In simulations calibrated to July 2020, our model suggests that waning immunity is virtually unimportant for centralized equilibria until at least 2021. This provides vital time for individuals and policy-makers to learn about immunity against SARS-CoV-2 before it becomes critical.

摘要

通过使用一个简单的经济模型,其中社会距离可减少传染,我们研究了免疫衰退对流行病学动态和社会活动的影响。如果免疫力下降,我们发现新冠病毒很可能会成为地方病,并且在发现疫苗或治愈方法之前,社会距离措施将持续存在。但是免疫衰退不一定会改变疫情爆发初期的最优行动。在接近感染峰值之前,分散均衡实际上与免疫衰退无关。对于集中均衡,免疫衰退的相关性会随着找到疫苗或治愈方法的概率、感染成本(例如感染死亡率)、部分免疫程度以及其他降低传染的非药物干预措施(例如隔离和戴口罩)的存在而降低。在根据2020年7月数据校准的模拟中,我们的模型表明,至少在2021年之前,免疫衰退对集中均衡几乎没有影响。这为个人和政策制定者在免疫力变得至关重要之前了解针对新冠病毒的免疫力提供了至关重要的时间。