Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Medicine (Baltimore). 2024 Apr 12;103(15):e37753. doi: 10.1097/MD.0000000000037753.
This study's goal is to evaluate if there is a causal connection between rheumatoid arthritis (RA) and age-related macular degeneration (AMD), despite past epidemiological studies suggesting an association between the 2 disorders. The impact of RA on AMD is still unknown. Mendelian randomization (MR) was utilized in this study to assess the two-sample causal relationship between RA and AMD. Summary data from GWAS for RA and AMD in individuals with all European ancestries were gathered using the IEU GWAS database. The GWAS summary statistics of RA (14,361 RA patients and 43,923 healthy controls) and AMD (14,034 AMD patients and 91,214 controls participated) were obtained from the IEU GWAS database. After identifying suitable instrumental variables in line with the 3 MR assumptions, we conducted MR using the Mendelian randomization-Egger (MR-Egger), weighted median, and inverse variance weighting techniques. The MR-Egger intercept and MR-Polyvalent Residuals and Outliers methods were used to investigate the effects of horizontal pleiotropy. The leave-one-out strategy was used to prevent bias caused by certain single nucleotide polymorphisms. Sensitivity analysis was used to detect the heterogeneity. Using 50 single nucleotide polymorphisms as instrumental variables, this study examined the relationship between RA and AMD and discovered that RA increased the risk of AMD (inverse variance weighting odds ratio [OR] = 1.056, 95% confidence interval [CI] = 1.02-1.09, P = 5.44E-04; weighted median OR = 1.085, 95% CI = 1.04-1.14, P = 4.05E-04; MR-Egger OR = 1.074, 95% CI = 1.01-1.14, P = 2.18E-2). The current investigation demonstrated a causal link between AMD and RA. RA increased the risk of AMD. It is advised that future research concentrate on the processes underlying the relationship between RA and AMD.
这项研究的目的是评估类风湿关节炎（RA）和年龄相关性黄斑变性（AMD）之间是否存在因果关系，尽管过去的流行病学研究表明这两种疾病之间存在关联。RA 对 AMD 的影响尚不清楚。本研究采用孟德尔随机化（MR）来评估 RA 和 AMD 之间的两样本因果关系。使用 IEU GWAS 数据库，从具有所有欧洲血统的个体的 RA 和 AMD 的 GWAS 中收集汇总数据。从 IEU GWAS 数据库中获得 RA（14361 例 RA 患者和 43923 例健康对照）和 AMD（14034 例 AMD 患者和 91214 例对照）的 GWAS 汇总统计数据。在符合 3 个 MR 假设的情况下确定合适的工具变量后，我们使用 Mendelian randomization-Egger（MR-Egger）、加权中位数和逆方差加权技术进行 MR。使用 MR-Polyvalent Residuals and Outliers 方法评估水平多效性的影响。采用逐一剔除策略防止某些单核苷酸多态性引起的偏倚。采用敏感性分析检测异质性。本研究使用 50 个单核苷酸多态性作为工具变量，研究 RA 和 AMD 之间的关系，发现 RA 增加了 AMD 的风险（逆方差加权比值比[OR] = 1.056，95%置信区间[CI] = 1.02-1.09，P = 5.44E-04；加权中位数 OR = 1.085，95%CI = 1.04-1.14，P = 4.05E-04；MR-Egger OR = 1.074，95%CI = 1.01-1.14，P = 2.18E-2）。目前的研究表明 AMD 和 RA 之间存在因果关系。RA 增加了 AMD 的风险。建议未来的研究集中于 RA 和 AMD 之间关系的潜在过程。
