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吸食大麻与表观遗传年龄的提前有关。

Cannabis smoking is associated with advanced epigenetic age.

机构信息

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, BC, Canada.

Edwin S.H. Leong Healthy Aging Program, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

出版信息

Eur Respir J. 2024 May 2;63(5). doi: 10.1183/13993003.00458-2024. Print 2024 May.

DOI:10.1183/13993003.00458-2024
PMID:38609099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11063617/
Abstract

https://bit.ly/3x7s2CU

摘要

医学文献链接

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a05/11063617/eefeb31b2c2c/ERJ-00458-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a05/11063617/eefeb31b2c2c/ERJ-00458-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a05/11063617/eefeb31b2c2c/ERJ-00458-2024.01.jpg

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Current marijuana use is associated with lower circulating α-Klotho levels in US adults even after adjusting for tobacco use: A national cross-sectional analysis of NHANES.即使在对烟草使用情况进行校正之后,美国成年人当前吸食大麻仍与较低的循环α-klotho水平相关:一项对美国国家健康与营养检查调查(NHANES)的全国性横断面分析。
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DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort.中年长期大麻使用者的DNA甲基化谱:对一个代表性队列中已发表的大麻相关甲基化标记物的综合评估。
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本文引用的文献

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The Blood DNA Methylation Clock GrimAge Is a Robust Surrogate for Airway Epithelia Aging.血液DNA甲基化时钟GrimAge是气道上皮细胞衰老的可靠替代指标。
Biomedicines. 2022 Dec 1;10(12):3094. doi: 10.3390/biomedicines10123094.
2
Marijuana use and DNA methylation-based biological age in young adults.年轻人中使用大麻与基于 DNA 甲基化的生物年龄。
Clin Epigenetics. 2022 Oct 26;14(1):134. doi: 10.1186/s13148-022-01359-8.
3
Effect of marijuana smoking on lung function change in older ever tobacco smokers.吸食大麻对曾经吸烟的老年人肺功能变化的影响。
Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation.
尽管已经戒烟,但吸食大麻仍与全基因组范围的持续性表观遗传破坏有关。
BMC Pulm Med. 2025 Apr 9;25(1):168. doi: 10.1186/s12890-025-03634-9.
4
ERJ advances: epigenetic ageing and leveraging DNA methylation in chronic respiratory diseases.《欧洲呼吸杂志》进展:表观遗传衰老与慢性呼吸道疾病中DNA甲基化的应用
Eur Respir J. 2024 Nov 14;64(5). doi: 10.1183/13993003.01257-2024. Print 2024 Nov.
5
Epigenetics and aging: relevance for sleep medicine.表观遗传学与衰老:对睡眠医学的意义。
Curr Opin Pulm Med. 2024 Nov 1;30(6):607-612. doi: 10.1097/MCP.0000000000001109. Epub 2024 Jul 31.
Eur Respir J. 2022 Sep 22;60(3). doi: 10.1183/13993003.01133-2022. Print 2022 Sep.
4
Epigenetic blood biomarkers of ageing and mortality in COPD.慢性阻塞性肺疾病(COPD)中衰老和死亡率的表观遗传血液生物标志物
Eur Respir J. 2021 Dec 16;58(6). doi: 10.1183/13993003.01890-2021. Print 2021 Dec.
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The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of Studies.大麻素对促炎和抗炎细胞因子的影响:研究的系统评价。
Cannabis Cannabinoid Res. 2021 Jun;6(3):177-195. doi: 10.1089/can.2020.0105. Epub 2021 Apr 28.
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Self-Reported Cannabis Use and Markers of Inflammation in Men Who Have Sex With Men With and Without HIV.自我报告的大麻使用情况与 HIV 阳性和阴性男男性行为者的炎症标志物。
Cannabis Cannabinoid Res. 2021 Apr 15;6(2):165-173. doi: 10.1089/can.2019.0083. eCollection 2021 Apr.
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Thorax. 2021 May;76(5):448-455. doi: 10.1136/thoraxjnl-2020-215866. Epub 2020 Dec 18.
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Aging (Albany NY). 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684.