Bajt M L, Aggarwal S K
Toxicol Appl Pharmacol. 1985 Aug;80(1):97-107. doi: 10.1016/0041-008x(85)90104-8.
Pregnant rats were injected ip with 4 or 7 mg cisplatin/kg on gestation day (gd) 6 to study its effect on embryonal resorption. Serum concentrations of prolactin, luteinizing hormone (LH), and progesterone were determined by radioimmunoassay in pregnant rats, and related to the effects of cisplatin on the maintenance of pregnancy. The nocturnal prolactin surge on gd 9 was abolished in cisplatin-treated rats. Within 3 days after drug injection, LH concentrations decreased 39%, while serum progesterone decreased 63% by Day 10. A histochemical study of 20 alpha-hydroxysteroid dehydrogenase activity revealed no enzyme activity by gd 10. It is proposed that the cause of cisplatin-related embryonal resorption in rats may be due to decreases in hormone concentrations observed after drug treatment.
在妊娠第6天给怀孕大鼠腹腔注射4或7毫克/千克顺铂，以研究其对胚胎吸收的影响。通过放射免疫分析法测定怀孕大鼠血清中催乳素、促黄体生成素（LH）和孕酮的浓度，并将其与顺铂对维持妊娠的影响相关联。顺铂处理的大鼠在妊娠第9天夜间催乳素激增被消除。在药物注射后3天内，LH浓度下降了39%，而到第10天血清孕酮下降了63%。对20α-羟基类固醇脱氢酶活性的组织化学研究显示，到妊娠第10天没有酶活性。有人提出，大鼠中与顺铂相关的胚胎吸收的原因可能是药物治疗后观察到的激素浓度降低。
