Lawrence I E, Burden H W, Louis T M
J Reprod Fertil. 1978 May;53(1):131-6. doi: 10.1530/jrf.0.0530131.
Abdominal vagotomy on Day 8 of pregnancy in rats decreased the number of live fetuses at Day 16 and increased the number of resorbing fetuses. The activity of delta5-3beta-hydroxysteroid dehydrogenase (3beta-HSD) in the corpus luteum and interstitial gland, LH and progesterone values in plasma and progesterone values in ovarian tissue were all lower in vagotomized rats than in sham-operated controls. Ovarian PGF levels were not affected. We suggest that these effects were caused by a direct effect of vagotomy on LH secretion which in turn lowers 3beta-HSD activity and progesterone levels in ovarian tissue and plasma, leading to fetal resorption.
在大鼠妊娠第8天进行腹部迷走神经切断术，会使妊娠第16天的活胎数量减少，并增加吸收胎的数量。与假手术对照组相比，迷走神经切断术大鼠的黄体和间质腺中δ5-3β-羟基类固醇脱氢酶（3β-HSD）的活性、血浆中的促黄体生成素（LH）和孕酮值以及卵巢组织中的孕酮值均较低。卵巢前列腺素F（PGF）水平未受影响。我们认为，这些影响是由迷走神经切断术对LH分泌的直接作用引起的，这反过来又降低了卵巢组织和血浆中的3β-HSD活性和孕酮水平，导致胎儿吸收。
