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新型痛觉/抗痛觉监测仪与两种商业监测仪在全身麻醉中的开发、验证和比较。

Development, Validation, and Comparison of a Novel Nociception/Anti-Nociception Monitor against Two Commercial Monitors in General Anesthesia.

机构信息

Department of Electromechanics, System and Metal Engineering, Ghent University, 9052 Ghent, Belgium.

Department of Automation, Technical University Cluj-Napoca, Memorandumului Street 20, 400114 Cluj, Romania.

出版信息

Sensors (Basel). 2024 Mar 22;24(7):2031. doi: 10.3390/s24072031.

DOI:10.3390/s24072031
PMID:38610243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11013864/
Abstract

In this paper, we present the development and the validation of a novel index of nociception/anti-nociception (N/AN) based on skin impedance measurement in time and frequency domain with our prototype AnspecPro device. The primary objective of the study was to compare the Anspec-PRO device with two other commercial devices (Medasense, Medstorm). This comparison was designed to be conducted under the same conditions for the three devices. This was carried out during total intravenous anesthesia (TIVA) by investigating its outcomes related to noxious stimulus. In a carefully designed clinical protocol during general anesthesia from induction until emergence, we extract data for estimating individualized causal dynamic models between drug infusion and their monitored effect variables. Specifically, these are Propofol hypnotic drug to Bispectral index of hypnosis level and Remifentanil opioid drug to each of the three aforementioned devices. When compared, statistical analysis of the regions before and during the standardized stimulus shows consistent difference between regions for all devices and for all indices. These results suggest that the proposed methodology for data extraction and processing for AnspecPro delivers the same information as the two commercial devices.

摘要

本文提出了一种基于皮肤阻抗测量的新型伤害感受/抗伤害感受（N/AN）指数，并使用我们的原型 AnspecPro 设备对其进行了开发和验证。本研究的主要目的是将 Anspec-PRO 设备与另外两种商业设备（Medasense、Medstorm）进行比较。这三种设备的比较设计是在相同条件下进行的。这是在全凭静脉麻醉（TIVA）下通过研究与伤害性刺激相关的结果来进行的。在一项精心设计的全身麻醉期间的临床方案中，从诱导到苏醒，我们提取数据来估计药物输注与其监测的效应变量之间的个体化因果动态模型。具体来说，这些是丙泊酚催眠药物对催眠水平的双谱指数和瑞芬太尼阿片类药物对上述三种设备中的每一种。在进行比较时，对标准化刺激前后区域的统计分析表明，所有设备和所有指数的区域之间存在一致的差异。这些结果表明，用于 AnspecPro 数据提取和处理的建议方法与两种商业设备提供了相同的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/773c/11013864/d80f5a3a407b/sensors-24-02031-g015.jpg
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