Fukunaga M, Yielding K L
Mutat Res. 1979 Aug;62(1):35-42. doi: 10.1016/0027-5107(79)90221-5.
Propidium, a phenanthridinium dye similar to ethidium, did not induce petite mutations in non-growing yeast cells in contrast to ethidium. Combined exposure to ethidium and an excess of propidium for periods up to 2 h resulted in the expected petite induction expressed after subsequent plating on growth medium. As incubation was continued with propidium, the numbers of petites declined on subsequent plating whether the drug had been added before, during, or after the mutagenic treatment by ethidium. Propidium decreased petite induction by the monoazide analog of ethidium when applied before but not after photolytic attachment of the drug.
溴化丙锭是一种与溴化乙锭类似的菲啶鎓染料，与溴化乙锭不同的是，它不会在非生长状态的酵母细胞中诱导小菌落突变。与过量的溴化丙锭联合暴露长达2小时，会导致在随后接种到生长培养基上时出现预期的小菌落诱导现象。随着用溴化丙锭持续孵育，无论该药物是在溴化乙锭诱变处理之前、期间还是之后添加的，后续接种时小菌落的数量都会减少。当在药物光解附着之前而非之后应用时，溴化丙锭会降低溴化乙锭单叠氮类似物的小菌落诱导作用。
