福美双在鼠伤寒沙门氏菌艾姆斯试验菌株中的诱变活性。
Mutagenic activity of thiram in Ames tester strains of Salmonella typhimurium.
作者信息
Zdzienicka M, Zieleńska M, Tudek B, Szymczyk T
出版信息
Mutat Res. 1979 Sep;68(1):9-13. doi: 10.1016/0165-1218(79)90072-7.
The mutagenic activity of thiram was investigated in 4 histidine-requiring strains of Salmonella typhimurium (TA1535, TA100, TA1538, TA98) with and without activation by liver microsomes. In strains TA1535 and TA100, thiram induces mutations without metabolic activation. The presence of rat-liver microsome fraction, cysteine or glutathione abolish its mutagenic activity in these strains. In contrast, thiram requires metabolic activation for the expression of its mutagenic activity in TA1538 and TA98 strains. The compounds containing the sulphydryl group abolish mutagenic activity of thiram in these strains, too.
在有或无肝微粒体激活的情况下，对4种组氨酸需求型鼠伤寒沙门氏菌菌株（TA1535、TA100、TA1538、TA98）研究了福美双的诱变活性。在TA1535和TA100菌株中，福美双无需代谢激活即可诱导突变。大鼠肝微粒体组分、半胱氨酸或谷胱甘肽的存在会消除其在这些菌株中的诱变活性。相比之下，福美双在TA1538和TA98菌株中表达诱变活性需要代谢激活。含巯基的化合物也会消除福美双在这些菌株中的诱变活性。
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