Shamaeli Ehsan, Alizadeh Naader
Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.
Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.
Int J Pharm. 2014 Sep 10;472(1-2):327-38. doi: 10.1016/j.ijpharm.2014.06.036. Epub 2014 Jun 23.
Biocompatible nanostructured conductive heparin-doped polypyrrole film was fabricated and employed as a high-capacity cation exchanger for programmable release of neuroleptic drug, chlorpromazine (CPZ) with thermally and electrical dual-stimulation. Releasing behavior were studied at different applied potentials and temperatures by in-situ monitoring of UV absorbance measurements. Three mathematical models (Higuchi, Power, and Avrami equation) were employed to investigate kinetics of the release. Based on the obtained results, the Avrami model found to be more comprehensive than two other ones for mathematical description of electro-stimulated release of CPZ. A quantitative relationship between activation energy parameters (Ea, ΔG(≠), ΔH(≠), and ΔS(≠)) and release conditions (applied potential and temperature) has been developed and established to predict release rate constants at various applied conditions.
制备了具有生物相容性的纳米结构导电肝素掺杂聚吡咯薄膜，并将其用作高容量阳离子交换剂，用于在热和电双刺激下可程控释放抗精神病药物氯丙嗪（CPZ）。通过原位监测紫外吸光度测量，研究了在不同施加电位和温度下的释放行为。采用三个数学模型（Higuchi模型、幂模型和Avrami方程）来研究释放动力学。基于所得结果，发现Avrami模型在数学描述CPZ的电刺激释放方面比其他两个模型更全面。已建立并确立了活化能参数（Ea、ΔG(≠)、ΔH(≠)和ΔS(≠)）与释放条件（施加电位和温度）之间的定量关系，以预测各种施加条件下的释放速率常数。
