Bogdanchikova Nina, Luna Vazquez-Gomez Roberto, Nefedova Ekaterina, Garibo Diana, Pestryakov Alexey, Plotnikov Evgenii, Shkil Nikolay N
Center for Nanoscience and Nanotechnology, National Autonomous University, Ensenada 22800, Mexico.
School of Health Sciences, Autonomous University of Baja California, Ensenada 22890, Mexico.
Materials (Basel). 2024 Apr 2;17(7):1629. doi: 10.3390/ma17071629.
The growing resistance of bacteria to antibiotics is one of the main public health problems nowadays. The influence of silver nanoparticle (AgNP) pretreatment of 220 cows with mastitis on the susceptibility of bacteria to 31 antibiotics was studied. The obtained results were compared with the previous results for , , and . For all four bacteria, an increase in susceptibility (9.5-21.2%) to 31 antibiotics after cow treatment with AgNPs was revealed, while after first-line antibiotic drug treatment as expected, the susceptibility decreased (11.3-27.3%). These effects were explained by (1) the increase in the contribution of isolates with efflux effect after antibiotic treatments and its decrease after AgNP treatment and (2) the changes in bacteria adhesion and anti-lysozyme activity after these treatments. The effect of the increasing antibacterial activity of antibiotics after AgNP treatment was the most pronounced in the case of and was minimal in the case of . With AgNP treatment, the time of recovery decreased by 26.8-48.4% compared to the time of recovery after treatment with the first-line antibiotic drugs. The AgNP treatment allows for achieving the partial restoration of the activity of antibiotics.
细菌对抗生素的耐药性不断增强是当今主要的公共卫生问题之一。研究了用银纳米颗粒（AgNP）预处理220头患乳腺炎奶牛对细菌对31种抗生素敏感性的影响。将所得结果与之前关于[此处原文缺失具体内容]的结果进行了比较。对于所有四种细菌，在用AgNPs处理奶牛后，其对31种抗生素的敏感性增加（9.5 - 21.2%），而如预期的那样，在一线抗生素药物治疗后，敏感性降低（11.3 - 27.3%）。这些影响的原因如下：（1）抗生素治疗后具有外排作用的分离株的贡献增加，而AgNP处理后其贡献减少；（2）这些处理后细菌粘附和抗溶菌酶活性的变化。在[此处原文缺失具体内容]的情况下，AgNP处理后抗生素抗菌活性增加的效果最为明显，而在[此处原文缺失具体内容]的情况下最小。与一线抗生素药物治疗后的恢复时间相比，AgNP处理使恢复时间减少了26.8 - 48.4%。AgNP处理能够实现抗生素活性的部分恢复。
