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黄体期不同剂量孕激素支持反映了冷冻胚胎移植周期中子宫内膜 microRNA 表达的变化。

Different Dosages of Progesterone in Luteal Phase Support Reflect Varying Endometrial microRNA Expression in Frozen Embryo Transfer Cycles.

机构信息

Department of Infertility and Reproductive Medicine, Taiwan IVF Group Center, Hsinchu 30274, Taiwan.

Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

出版信息

Int J Mol Sci. 2024 Mar 25;25(7):3670. doi: 10.3390/ijms25073670.

DOI:10.3390/ijms25073670
PMID:38612482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11011508/
Abstract

Despite serum progesterone being a widely accepted method for luteal phase support during embryo transfer cycles, debates persist regarding the optimal strategy for guiding clinical decisions on progesterone dosages to maximize reproductive outcomes. This retrospective study explored the utility of microRNA (miRNA) biomarkers in guiding personalized progesterone dosage adjustments for frozen embryo transfer (FET) cycles in 22 in vitro fertilization (IVF) patients undergoing hormone replacement therapy. Utilizing MIRA, an miRNA-based endometrial receptivity test, we analyzed patients' miRNA expression profiles before and after progesterone dosage adjustments to determine suitable dosages and assess endometrial status. Despite patients receiving identical progesterone dosages, variations in miRNA profiles were observed in the initial cycle, and all patients presented a displaced window of implantation. Following dosage adjustments based on their miRNA profiles, 91% of patients successfully transitioned their endometrium towards the receptive stages. However, two patients continued to exhibit persistent displaced receptivity despite the adjustments. Given the evident variation in endometrial status and serum progesterone levels among individuals, analyzing miRNA expression profiles may address the challenge of inter-personal variation in serum progesterone levels, to deliver more personalized dosage adjustments and facilitate personalized luteal phase support in IVF.

摘要

尽管血清孕激素是胚胎移植周期黄体支持的一种广泛接受的方法，但关于指导孕激素剂量临床决策以最大化生殖结局的最佳策略仍存在争议。这项回顾性研究探讨了 miRNA（microRNA）生物标志物在指导 22 名接受激素替代治疗的体外受精 (IVF) 患者冷冻胚胎移植 (FET) 周期个体化孕激素剂量调整中的应用。该研究使用基于 miRNA 的子宫内膜容受性测试 MIRA，分析了患者在孕激素剂量调整前后的 miRNA 表达谱，以确定合适的剂量并评估子宫内膜状态。尽管患者接受了相同的孕激素剂量，但在初始周期中观察到 miRNA 谱存在差异，所有患者均出现了着床窗偏移。根据他们的 miRNA 谱进行剂量调整后，91%的患者成功地将其子宫内膜向接受状态转变。然而，尽管进行了调整，仍有两名患者持续表现出持续的着床窗偏移。鉴于个体之间子宫内膜状态和血清孕激素水平存在明显差异，分析 miRNA 表达谱可能有助于解决血清孕激素水平个体间差异的挑战，以提供更个体化的剂量调整，并促进 IVF 中的个体化黄体支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e93c/11011508/762bee545757/ijms-25-03670-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e93c/11011508/3cf3668ce8bb/ijms-25-03670-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e93c/11011508/8349c76fb80c/ijms-25-03670-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e93c/11011508/762bee545757/ijms-25-03670-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e93c/11011508/3cf3668ce8bb/ijms-25-03670-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e93c/11011508/8349c76fb80c/ijms-25-03670-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e93c/11011508/762bee545757/ijms-25-03670-g003.jpg

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Commercially Available Molecular Approaches to Evaluate Endometrial Receptivity: A Systematic Review and Critical Analysis of the Literature.评估子宫内膜容受性的商用分子方法：文献的系统评价与批判性分析
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