Maziotis Evangelos, Kalampokas Theodoros, Giannelou Polina, Grigoriadis Sokratis, Rapani Anna, Anifantakis Marios, Kotsifaki Amalia, Pantou Agni, Triantafyllidou Olga, Tzanakaki Despoina, Neofytou Spyridoula, Vogiatzi Paraskevi, Bakas Panagiotis, Simopoulou Mara, Vlahos Nikolaos
Department of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Str., 11527 Athens, Greece.
Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, Greece.
Diagnostics (Basel). 2022 Oct 27;12(11):2611. doi: 10.3390/diagnostics12112611.
Despite the advances in the field of reproductive medicine, implantation failure represents a challenging condition affecting 10-30% of patients subjected to in vitro fertilization (IVF). Research has focused on the identification of molecules playing crucial roles in endometrial receptivity, with the aim of designing predictive tools for efficient detection of the implantation window. To that end, novel molecular genomic and transcriptomic approaches have been introduced as promising tools to enable personalized approaches with the aim of optimizing embryo transfer dating. However, the clinical value of these approaches remains unclear. The aim of this study is to provide a systematic review and critical analysis of the existing evidence regarding the employment of commercially available novel approaches to evaluate endometrial receptivity. An Embase and PubMed/Medline search was performed on 1 February 2022. From the 475 articles yielded, only 27 were included and analyzed. The considerable heterogeneity of the included articles indicates the uniqueness of the implantation window, showcasing that the optimal time for embryo transfer varies significantly between women. Moreover, this study provides information regarding the technical aspects of these advanced molecular tools, as well as an analysis of novel possible biomarkers for endometrial receptivity, providing a basis for future research in the field.
尽管生殖医学领域取得了进展，但着床失败仍是一个具有挑战性的问题，影响着10%-30%接受体外受精（IVF）的患者。研究集中在鉴定在子宫内膜容受性中起关键作用的分子，目的是设计预测工具以有效检测着床窗。为此，新型分子基因组学和转录组学方法已作为有前景的工具被引入，以实现个性化方法，旨在优化胚胎移植时间。然而，这些方法的临床价值仍不明确。本研究的目的是对现有证据进行系统综述和批判性分析，这些证据涉及使用市售新型方法评估子宫内膜容受性。于2022年2月1日进行了Embase和PubMed/Medline检索。从检索出的475篇文章中，仅纳入并分析了27篇。纳入文章的显著异质性表明着床窗的独特性，显示出女性之间胚胎移植的最佳时间差异很大。此外，本研究提供了有关这些先进分子工具技术方面的信息，以及对子宫内膜容受性新的可能生物标志物的分析，为该领域的未来研究提供了基础。
