Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Division of Health Sciences and Technology, Massachusetts Institute of Technology, Harvard University, Cambridge, MA 02139, USA.
Int J Mol Sci. 2024 Mar 29;25(7):3811. doi: 10.3390/ijms25073811.
The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. This review explores the principles of PDT and discusses the concept of photodynamic priming (PDP), which augments the effectiveness of treatments like chemotherapy. Furthermore, the integration of nanotechnology for precise drug delivery at the right time and location and PDT optimization are examined. Ultimately, this study highlights the potential and limitations of PDT and PDP in cancer treatment paradigms, offering insights into future clinical applications.
标准化疗的持续失败突显了癌症治疗中创新和靶向方法的迫切需求。光动力疗法（PDT）作为一种有前途的基于光化学的方法，已经出现以解决癌症治疗方案中的化疗耐药性。PDT 不仅诱导细胞死亡，还启动存活细胞，增强它们对后续治疗的敏感性。本综述探讨了 PDT 的原理，并讨论了光动力引发（PDP）的概念，该概念增强了化疗等治疗方法的效果。此外，还研究了纳米技术在正确的时间和位置进行精确药物输送和 PDT 优化的整合。最终，本研究强调了 PDT 和 PDP 在癌症治疗模式中的潜力和局限性，为未来的临床应用提供了见解。
