Tain You-Lin, Hou Chih-Yao, Chang-Chien Guo-Ping, Lin Sufan, Hsu Chien-Ning
Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Antioxidants (Basel). 2023 Nov 29;12(12):2059. doi: 10.3390/antiox12122059.
Taurine is a natural antioxidant with antihypertensive properties. Maternal chronic kidney disease (CKD) has an impact on renal programming and increases the risk of offspring hypertension in later life. The underlying mechanisms cover oxidative stress, a dysregulated hydrogen sulfide (HS) system, dysbiotic gut microbiota, and inappropriate activation of the renin-angiotensin-aldosterone system (RAAS). We investigated whether perinatal taurine administration enables us to prevent high blood pressure (BP) in offspring complicated by maternal CKD. Before mating, CKD was induced through feeding chow containing 0.5% adenine for 3 weeks. Taurine was administered (3% in drinking water) during gestation and lactation. Four groups of male offspring were used ( = 8/group): controls, CKD, taurine-treated control rats, and taurine-treated rats with CKD. Taurine treatment significantly reduced BP in male offspring born to mothers with CKD. The beneficial effects of perinatal taurine treatment were attributed to an augmented HS pathway, rebalance of aberrant RAAS activation, and gut microbiota alterations. In summary, our results not only deepen our knowledge of the mechanisms underlying maternal CKD-induced offspring hypertension but also afford us the impetus to consider taurine-based intervention as a promising preventive approach for future clinical translation.
牛磺酸是一种具有抗高血压特性的天然抗氧化剂。母体慢性肾脏病（CKD）会影响肾脏编程，并增加后代成年后患高血压的风险。其潜在机制包括氧化应激、硫化氢（HS）系统失调、肠道微生物群失调以及肾素-血管紧张素-醛固酮系统（RAAS）的不适当激活。我们研究了围产期给予牛磺酸是否能够预防因母体CKD而导致的后代高血压。在交配前，通过喂食含0.5%腺嘌呤的饲料3周来诱导CKD。在妊娠和哺乳期给予牛磺酸（饮用水中含3%）。使用了四组雄性后代（每组n = 8）：对照组、CKD组、牛磺酸处理的对照大鼠组以及牛磺酸处理的CKD大鼠组。牛磺酸治疗显著降低了患有CKD的母亲所生雄性后代的血压。围产期牛磺酸治疗的有益作用归因于HS途径增强、异常RAAS激活的重新平衡以及肠道微生物群的改变。总之，我们的研究结果不仅加深了我们对母体CKD诱发后代高血压潜在机制的认识，也促使我们考虑将基于牛磺酸的干预措施作为未来临床转化中一种有前景的预防方法。
