Lamontagne Felix, Paz-Trejo Cynthia, Zamorano Cuervo Natalia, Grandvaux Nathalie
CRCHUM - Centre de Recherche du Centre Hospitalier de l'Université de Montréal, 900 rue Saint Denis, Montréal H2X 0A9, Québec, Canada.
CRCHUM - Centre de Recherche du Centre Hospitalier de l'Université de Montréal, 900 rue Saint Denis, Montréal H2X 0A9, Québec, Canada; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal H3C 3J7, Québec, Canada.
Biochim Biophys Acta Mol Cell Res. 2024 Jun;1871(5):119722. doi: 10.1016/j.bbamcr.2024.119722. Epub 2024 Apr 12.
This review explores the nuanced role of reactive oxygen species (ROS) in cell fate, challenging the traditional view that equates ROS with cellular damage. Through significant technological advancements in detecting localized redox states and identifying oxidized cysteines, a paradigm shift has emerged: from ROS as merely damaging agents to crucial players in redox signaling. We delve into the intricacies of redox mechanisms, which, although confined, exert profound influences on cellular physiological responses. Our analysis extends to both the positive and negative impacts of these mechanisms on cell death processes, including uncontrolled and programmed pathways. By unraveling these complex interactions, we argue against the oversimplified notion of a 'stress response', advocating for a more nuanced understanding of redox signaling. This review underscores the importance of localized redox states in determining cell fate, highlighting the sophistication and subtlety of ROS functions beyond mere damage.
本综述探讨了活性氧（ROS）在细胞命运中所扮演的微妙角色，对将ROS等同于细胞损伤的传统观点提出了挑战。随着检测局部氧化还原状态和识别氧化半胱氨酸的技术取得重大进展，一种范式转变已然出现：从认为ROS仅仅是破坏因子，转变为认识到它们是氧化还原信号传导中的关键参与者。我们深入研究氧化还原机制的复杂性，这些机制虽有限，但对细胞生理反应有着深远影响。我们的分析涵盖了这些机制对细胞死亡过程的正负两方面影响，包括失控和程序性途径。通过揭示这些复杂的相互作用，我们反对“应激反应”这种过于简单化的概念，主张对氧化还原信号传导有更细致入微的理解。本综述强调了局部氧化还原状态在决定细胞命运中的重要性，突出了ROS功能的复杂性和微妙性，而不仅仅是损伤作用。
