Zhang Aiping, Wang Zijian, Sheng Haoyu, Yang Jianghua
Department of Infectious Diseases, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, 241001, People's Republic of China.
Infect Drug Resist. 2024 Dec 20;17:5739-5744. doi: 10.2147/IDR.S483524. eCollection 2024.
() can cause fungal infections in near-drowning victims, and an increasing number of cases have been reported. However, cases of bone and joint infections caused by are rare. In this case, a 35-year-old otherwise healthy Chinese female presented with aspiration pneumonia and knee arthritis after accidentally falling into sewage and near-drowning and underwent macrogenomic second-generation sequencing of arthrocentesis fluid, which showed . However, new lesions involving the hip joint and spine continued to develop under voriconazole monotherapy. The patient was treated with voriconazole combined with amphotericin B cholesterol sulfate lipid complex for 30 consecutive days. The patient's symptoms improved significantly. This case highlights the robust invasiveness of and the extensive spread of infection, underscoring the importance of prompt diagnosis and treatment. A combined therapeutic approach may offer a safe and efficacious option for managing infection.
（）可导致近乎溺水者发生真菌感染，且报告的病例数量不断增加。然而，由（）引起的骨和关节感染病例罕见。在此病例中，一名35岁、其他方面健康的中国女性在意外跌入污水并近乎溺水后出现吸入性肺炎和膝关节炎，并对关节穿刺液进行了宏基因组第二代测序，结果显示（）。然而，在伏立康唑单药治疗下，累及髋关节和脊柱的新病灶仍不断出现。该患者接受了伏立康唑联合两性霉素B胆固醇硫酸酯脂质体复合物连续治疗30天。患者症状明显改善。该病例突出了（）强大的侵袭性和感染的广泛传播，强调了及时诊断和治疗的重要性。联合治疗方法可能为管理（）感染提供一种安全有效的选择。
