Modified Release Studies on Melatoninergic Fluorinated Phenylalkylamides: Circumventing their Lipophilicity for Oral Administration.

INTRODUCTION

In an attempt to circumvent the lipophilicity burden for the oral administration of new potent synthetic melatoninergic fluorine-substituted methoxyphenylalkyl amides, we conducted modified release studies using carefully selected matrix tablets' biopolymeric materials in different ratios.

METHODS

In particular, we sought to attain release profiles of these analogues similar to that of the parent compound, the chronobiotic hormone Melatonin (MLT), and also of the commercially available drug, Circadin.

RESULTS

It was found that some of these systems, albeit being more lipophilic than MLT, mimic the release patterns of melatonin and Circadin.

CONCLUSION

Moreover, a number of these derivatives were proven suitable for dealing with sleep onset problems, whilst others for dealing with combined sleep onset/sleep maintenance dysfunctions.