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恶性脑肿瘤的尸检磁共振成像与病理结果的对比研究

Comparative Study of Postmortem MRI and Pathological Findings in Malignant Brain Tumors.

作者信息

Saito Norihiko, Hirai Nozomi, Koyahara Yuki, Sato Sho, Hiramoto Yu, Fujita Satoshi, Nakayama Haruo, Hayashi Morito, Ito Keisuke, Iwabuchi Satoshi

机构信息

Neurosurgery, Toho University Ohashi Medical Center, Tokyo, JPN.

出版信息

Cureus. 2024 Mar 15;16(3):e56241. doi: 10.7759/cureus.56241. eCollection 2024 Mar.

DOI:10.7759/cureus.56241
PMID:38618299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11016320/
Abstract

This study compared magnetic resonance imaging (MRI) findings of postmortem brain specimens with neuropathological findings to evaluate the value of postmortem MRI. Postmortem MRI was performed on five formalin-fixed whole brains with malignant tumors. Postmortem T2-weighted images detected all neuropathological abnormalities as high-signal regions but also showed histological tumor invasion in areas without edema. Tumor lesions with high necrosis and edema showed high signal intensity on T2-weighted images; in three cases, lesion enlargement was detected on the final prenatal imaging and postmortem MRI. Disease progression immediately before death may have contributed to this difference. In conclusion, the correlation between MRI and neuropathological findings facilitates understanding of the mechanisms responsible for MRI abnormalities. Increased free water due to edema, necrosis, and brain tissue injury can explain the increased signal intensity observed on T2-weighted images. Postmortem MRI may contribute to effective pathology by identifying subtle abnormalities prior to brain dissection.

摘要

本研究将死后脑标本的磁共振成像（MRI）结果与神经病理学结果进行比较，以评估死后MRI的价值。对五个患有恶性肿瘤的福尔马林固定全脑进行了死后MRI检查。死后T2加权图像将所有神经病理学异常检测为高信号区域，但也显示出在无水肿区域存在组织学肿瘤浸润。坏死和水肿程度高的肿瘤病变在T2加权图像上显示为高信号强度；在三例病例中，在产前最后一次成像和死后MRI上均检测到病变增大。死亡前疾病的进展可能导致了这种差异。总之，MRI与神经病理学结果之间的相关性有助于理解导致MRI异常的机制。水肿、坏死和脑组织损伤导致的游离水增加可以解释T2加权图像上观察到的信号强度增加。死后MRI可能通过在脑解剖前识别细微异常而有助于有效的病理学研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/3ee4e6c3407a/cureus-0016-00000056241-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/3a11d0d2fee7/cureus-0016-00000056241-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/abddaad1b841/cureus-0016-00000056241-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/7b0eabbd90d7/cureus-0016-00000056241-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/682a755bc85c/cureus-0016-00000056241-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/5575880d0515/cureus-0016-00000056241-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/2c84b442659a/cureus-0016-00000056241-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/7c8492fa181e/cureus-0016-00000056241-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/3ee4e6c3407a/cureus-0016-00000056241-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/3a11d0d2fee7/cureus-0016-00000056241-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/abddaad1b841/cureus-0016-00000056241-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/7b0eabbd90d7/cureus-0016-00000056241-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/682a755bc85c/cureus-0016-00000056241-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/5575880d0515/cureus-0016-00000056241-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/2c84b442659a/cureus-0016-00000056241-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/7c8492fa181e/cureus-0016-00000056241-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa1f/11016320/3ee4e6c3407a/cureus-0016-00000056241-i08.jpg

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Postmortem 7T MRI for guided histopathology and evaluation of cerebrovascular disease.用于指导组织病理学和脑血管病评估的死后 7T MRI。
J Neuropathol Exp Neurol. 2022 Dec 19;82(1):57-70. doi: 10.1093/jnen/nlac103.
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Postmortem study of organ-specific toxicity in glioblastoma patients treated with a combination of temozolomide, irinotecan and bevacizumab.
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Pediatr Radiol. 2022 Feb;52(2):217-227. doi: 10.1007/s00247-021-05042-7. Epub 2021 Apr 15.
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