van den Hauwe L, Parizel P M, Martin J J, Cras P, De Deyn P, De Schepper A M
Department of Radiology, Universitair Ziekenhuis Antwerpen, University of Antwerp, Belgium.
Neuroradiology. 1995 Jul;37(5):343-9. doi: 10.1007/BF00588007.
We prospectively correlated in vitro MRI of the brain with the neuropathological findings in patients with suspected intracranial disease. In vitro MRI was performed on 91 consecutive formalin-fixed whole-brain specimens. In 60 cases, the images were correlated with the neuropathological findings (number of lesions, lesion boundaries, spread of oedema and type of lesions). As compared with neuropathology, MRI showed an equal number of lesions in 50 cases, more in 5, and less in 5 specimens, resulting in a sensitivity of 83.3%. The extent of perilesional oedema was better seen on in vitro MRI than on gross pathology. Microscopic extent of glial tumours was underestimated on both T2-weighted images and macroscopic examination. Neuropathology remains the reference study, since on in vitro MRI primary brain tumours, metastatic deposits and non-neoplastic space-occupying lesions cannot be differentiated. However, in our study MRI had a specificity of 76.6%. MRI of postmortem specimens is sensitive to focal brain lesions, and can focus the attention of the neuropathologist to abnormal regions.
我们对疑似颅内疾病患者的脑部进行了前瞻性体外磁共振成像（MRI）与神经病理学结果的相关性研究。对91个连续的经福尔马林固定的全脑标本进行了体外MRI检查。在60例病例中，将图像与神经病理学结果（病变数量、病变边界、水肿范围和病变类型）进行了相关性分析。与神经病理学相比，MRI在50例病例中显示的病变数量相同，5例中显示的病变更多，5例中显示的病变更少，灵敏度为83.3%。体外MRI比大体病理学更能清晰显示病变周围水肿的范围。在T2加权图像和大体检查中，胶质肿瘤的微观范围均被低估。神经病理学仍是参考研究，因为在体外MRI上无法区分原发性脑肿瘤、转移瘤和非肿瘤性占位性病变。然而，在我们的研究中，MRI的特异性为76.6%。死后标本的MRI对局灶性脑病变敏感，可将神经病理学家的注意力集中在异常区域。
