From the Department of Radiology and Neurology, Southern TOHOKU General Hospital.
Drug Discovery and Cyclotron Research Center, Southern TOHOKU Research Institute for Neuroscience, Koriyama, Japan.
Clin Nucl Med. 2024 Jun 1;49(6):e281-e283. doi: 10.1097/RLU.0000000000005173. Epub 2024 Apr 12.
Cerebral amyloid angiopathy-related inflammation is a rare encephalopathy characterized by inflammation against amyloid protein accumulated in cerebral small vessels. A 50-year-old man was presented with a subacute consciousness disorder. Brain MRI revealed high intensity lesions in the white matter of the right parietal and occipital lobes on fluid-attenuated inversion recovery sequences and cerebral microbleeds in the right parietal and occipital lobes on T2*-weighted images. Pittsburgh compound B-PET demonstrated accumulation in the right temporoparietal lobe, confirming a potential diagnosis of probable cerebral amyloid angiopathy-related inflammation without brain biopsy. Steroid pulse therapy was initiated, with good results.
脑淀粉样血管病相关性炎症是一种罕见的中枢神经系统疾病，其特征为大脑小血管中淀粉样蛋白沉积引发的炎症反应。一名 50 岁男性以亚急性意识障碍为表现就诊。头颅 MRI 显示右侧顶枕叶脑白质在液体衰减反转恢复序列上呈高信号，右侧顶枕叶在 T2*-weighted 图像上可见脑微出血。匹兹堡化合物 B-PET 显示右侧颞顶叶放射性摄取增加，支持可能的脑淀粉样血管病相关性炎症的诊断，未进行脑组织活检。给予患者激素冲击治疗，取得了良好的效果。
