Sisk A L, Bonnington G J
Oral Surg Oral Med Oral Pathol. 1985 Aug;60(2):137-45. doi: 10.1016/0030-4220(85)90281-6.
The ideal anti-inflammatory agent for use in third molar surgery should control pain, reduce swelling and trismus, and have no unwanted side effects. This investigation evaluated and compared the efficacy of corticosteroids, nonsteroidal anti-inflammatory agents, and placebo for reduction of the acute postoperative inflammatory response and its undesirable sequelae in patients undergoing the surgical removal of impacted third molars. Corticosteroids appeared to have maximal effect in controlling edema but had minimal analgesic effects. Nonsteroidal anti-inflammatory agents appear to be effective analgesics. A combination of these agents may be necessary to control the sequelae of oral surgical procedures most effectively.
用于第三磨牙手术的理想抗炎药应能控制疼痛、减轻肿胀和牙关紧闭，且无不良副作用。本研究评估并比较了皮质类固醇、非甾体抗炎药和安慰剂在接受阻生第三磨牙拔除术的患者中减轻术后急性炎症反应及其不良后遗症的疗效。皮质类固醇在控制水肿方面似乎有最大效果，但镇痛效果最小。非甾体抗炎药似乎是有效的镇痛药。可能需要联合使用这些药物才能最有效地控制口腔外科手术的后遗症。
