Beirne O R, Hollander B
Oral Surg Oral Med Oral Pathol. 1986 Feb;61(2):134-8. doi: 10.1016/0030-4220(86)90173-8.
Thirty-one healthy patients whose third molars needed to be removed were randomly placed into two groups. Before sedation the control group (n = 16) received normal saline solution and the experimental group (n = 15) received 125 mg of methylprednisolone intravenously. Swelling was measured by photographic and face-bow techniques, trismus was determined by measuring maximal interincisal opening, and pain was evaluated by asking the patients to report the number of pain pills they used and assess th severity of their pain daily. The swelling and pain, but not the trismus, that developed after third molar removal were significantly reduced by a single dose of methylprednisolone.
31名需要拔除第三磨牙的健康患者被随机分为两组。在镇静前，对照组（n = 16）接受生理盐水溶液，实验组（n = 15）静脉注射125毫克甲泼尼龙。通过摄影和面部测量技术测量肿胀程度，通过测量最大切牙间开口度确定牙关紧闭情况，并通过询问患者报告所服用止痛片的数量以及每天评估疼痛严重程度来评估疼痛。拔除第三磨牙后出现的肿胀和疼痛（而非牙关紧闭），通过单剂量甲泼尼龙得到了显著减轻。
