布洛芬和甲基强的松龙用于预防阻生第三磨牙拔除术后疼痛和肿胀。
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
作者信息
Schultze-Mosgau S, Schmelzeisen R, Frölich J C, Schmele H
机构信息
Institute of Clinical Pharmacology of Hannover Medical School, Germany.
出版信息
J Oral Maxillofac Surg. 1995 Jan;53(1):2-7; discussion 7-8. doi: 10.1016/0278-2391(95)90486-7.
PURPOSE
To test a combination treatment of ibuprofen and methylprednisolone for pain and swelling.
METHODS
The efficacy of 32 mg methylprednisolone on pain and swelling when given 12 hours before and after surgery in combination with 400 mg ibuprofen three times a day given immediately on the day of the operation and on the two subsequent days following removal of impacted third molars was investigated in a placebo-controlled, intraindividual double-blind study.
RESULTS
After use of ibuprofen/methylprednisolone, ultrasonic examination showed a reduction in swelling of 56% (P < .001) compared with the placebo group; measurement with a tape measure showed a 58% (P < .001) reduction in swelling. The visual analog scale showed a reduction of 67.7% in postoperative pain in comparison with placebo.
CONCLUSION
The combination of ibuprofen and methylprednisolone has good analgesic and antiinflammatory action.
目的
测试布洛芬与甲泼尼龙联合治疗疼痛和肿胀的效果。
方法
在一项安慰剂对照的个体内双盲研究中，研究了32毫克甲泼尼龙在手术前12小时和手术后给予，与400毫克布洛芬在手术当天及拔除阻生第三磨牙后的随后两天每天三次立即给药联合使用时，对疼痛和肿胀的疗效。
结果
使用布洛芬/甲泼尼龙后，超声检查显示与安慰剂组相比肿胀减少了56%（P <.001）；用卷尺测量显示肿胀减少了58%（P <.001）。视觉模拟量表显示与安慰剂相比术后疼痛减少了67.7%。
结论
布洛芬与甲泼尼龙联合使用具有良好的镇痛和抗炎作用。
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