The First Clinical Medical College, Beijing University of Chinese Medicine, Beijing, China.
Dongzhimen Hospital, Beijing University of Chinese Medicine, 5 Haiyuncang, Dongcheng District, Beijing, 100700, China.
Sci Rep. 2024 Apr 16;14(1):8726. doi: 10.1038/s41598-024-58030-w.
Chronic pain, a substantial public health issue, may be influenced by dietary patterns through systemic inflammation. This cross-sectional study explored the association between Dietary Inflammatory Index (DII) and chronic pain among 2581 American adults from NHANES data. The DII, ranging from - 4.98 to 4.69, reflects the inflammatory potential of the diet, with higher scores indicating greater pro-inflammatory capacity. Our findings showed no significant association between the continuous DII score and chronic pain prevalence. However, a nonlinear relationship emerged. When the DII was categorized, a significant association between higher DII scores (DII ≥ 2.5) and chronic pain prevalence was observed. The analysis uncovered a U-shaped pattern, with an inflection point at a DII score of - 0.9, indicating an association between both low and high levels of dietary inflammation are associated with higher pain prevalence. This nuanced interaction between dietary inflammation and chronic pain indicates the possibility of incorporating dietary modification into pain management strategies and underscores the need for further research into the long-term effects of diet on chronic pain.
慢性疼痛是一个严重的公共健康问题，可能会受到饮食模式通过系统性炎症的影响。本横断面研究通过 NHANES 数据分析了饮食炎症指数（DII）与美国 2581 名成年人慢性疼痛之间的关系。DII 的范围为-4.98 至 4.69，反映了饮食的炎症潜能，得分越高表示促炎能力越强。我们的研究结果表明，DII 连续评分与慢性疼痛患病率之间没有显著关联。然而，我们发现了一种非线性关系。当对 DII 进行分类时，观察到 DII 评分较高（DII≥2.5）与慢性疼痛患病率之间存在显著关联。分析揭示了一种 U 型模式，在 DII 评分为-0.9 时出现拐点，表明饮食炎症的低水平和高水平均与更高的疼痛患病率相关。这种饮食炎症与慢性疼痛之间的细微相互作用表明，将饮食改变纳入疼痛管理策略的可能性，并强调了进一步研究饮食对慢性疼痛的长期影响的必要性。
