The Third Affiliated Hospital of Beijing University of Chinese Medicine, No. 51, Xiaoguan Street, Outside Andingmen, Chaoyang District, Beijing, 100029, China.
Capital Medical University Beijing Hospital of Traditional Chinese Medicine, Beijing, China.
Sci Rep. 2024 Aug 14;14(1):18845. doi: 10.1038/s41598-024-69777-7.
Research on the potential association between life-ever gallstones and depressive symptoms is limited. This study aims to evaluate whether the presence of gallstone disease is associated with depressive symptoms. In this cross-sectional study, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020 cycles. The presence of depressive symptoms and gallstone disease was assessed using questionnaire responses. Adjusted odds ratios (OR) were calculated using a multivariate logistic regression model, with adjustments made for age, sex, race, body mass index, history of cardiovascular disease, hypertension, arthritis, and pulmonary disease across different models. Subgroup and sensitivity analyses were conducted to ensure the stability of the results. This study included 6201 adults aged 20 years and above, with 539(8.7%) experiencing depressive symptoms. After adjusting for age, sex, race, body mass index, CVD history, hypertension, arthritis, pulmonary disease, depressive symptoms were possibly associated with life-ever gallstones (OR 1.37, 95% CI 0.91-2.08).When depressive symptoms were categorized as mild, moderate, moderately severe, and severe,life-ever gallstones was possibly associated with mild depressive symptoms (OR 1.12, 95% CI 0.81-1.56), moderate depressive symptoms (OR 1.37, 95% CI 0.89-2.12), moderately severe depressive symptoms (OR 1.93, 95% CI 0.93-3.99), and severe depressive symptoms (OR 0.67, 95% CI 0.16-2.88).As a continuous variable, life-ever gallstones was associated with the PHQ-9 score (OR 0.42, 95% CI 0.02-0.83). The results remained stable after multiple imputation for all missing data. This cross-sectional study demonstrates no significant association between life-ever gallstones and depressive symptoms in US adults.
关于终身胆石症与抑郁症状之间潜在关联的研究有限。本研究旨在评估胆石病的存在是否与抑郁症状相关。在这项横断面研究中，我们分析了 2017 年至 2020 年 3 月国家健康和营养检查调查（NHANES）的数据。使用问卷回答评估抑郁症状和胆石症的存在。使用多变量逻辑回归模型计算调整后的优势比（OR），并在不同模型中调整了年龄、性别、种族、体重指数、心血管疾病史、高血压、关节炎和肺部疾病。进行了亚组和敏感性分析以确保结果的稳定性。这项研究包括 6201 名 20 岁及以上的成年人，其中 539 人（8.7%）出现抑郁症状。在调整了年龄、性别、种族、体重指数、心血管疾病史、高血压、关节炎和肺部疾病后，终身胆石症可能与抑郁症状相关（OR 1.37，95%CI 0.91-2.08）。当将抑郁症状分为轻度、中度、中度严重和重度时，终身胆石症可能与轻度抑郁症状相关（OR 1.12，95%CI 0.81-1.56）、中度抑郁症状（OR 1.37，95%CI 0.89-2.12）、中度严重抑郁症状（OR 1.93，95%CI 0.93-3.99）和严重抑郁症状（OR 0.67，95%CI 0.16-2.88）。作为一个连续变量，终身胆石症与 PHQ-9 评分相关（OR 0.42，95%CI 0.02-0.83）。在对所有缺失数据进行多次插补后，结果仍然稳定。这项横断面研究表明，美国成年人中终身胆石症与抑郁症状之间没有显著关联。
