Kong Mi-Sun, Kim Moon-Jong, Kim Yoon-Young, Chang Ji-Youn, Kho Hong-Seop
Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, South Korea.
Department of Oral Medicine, Gwanak Seoul National University Dental Hospital, Seoul, South Korea.
Oral Dis. 2024 Nov;30(8):5360-5369. doi: 10.1111/odi.14959. Epub 2024 Apr 15.
To investigate the clinical characteristics and salivary biomarkers in each type of burning mouth syndrome (BMS) patients.
Ninety-eight postmenopausal female patients with BMS were included. Fifty and 21 patients were assigned to the primary and secondary groups, respectively. Twenty-seven patients with both primary and secondary characteristics were assigned to the intermediate group. Comprehensive clinical characteristics and salivary biomarkers were analyzed.
Significant differences in age, proportion of hyposalivator patients based on unstimulated whole saliva (UWS), symptom distribution, severties of burning sensation and effect of oral complaints in daily life (Eff-life), and positive symptom distress index (PSDI) were observed among the three groups. The primary group had significant higher UWS flow rate, fewer UWS hyposalivator proportions, and lesser severity of Eff-life than the secondary group. The intermediate group had significantly greater intensities of burning sensation and Eff-life and higher PSDI score than did the primary group. The primary group had significantly higher cortisol and dehydroepiandrosterone (DHEA) levels in stimulated whole saliva than did the secondary group.
This study's findings show that clinical characteristics differentiate each BMS type. Cortisol and DHEA levels are potential salivary biomarkers for discriminating between the primary and secondary types of BMS.
研究各类型灼口综合征（BMS）患者的临床特征及唾液生物标志物。
纳入98例绝经后女性BMS患者。分别将50例和21例患者分配至原发性组和继发性组。27例兼具原发性和继发性特征的患者被分配至中间组。分析综合临床特征和唾液生物标志物。
三组患者在年龄、基于非刺激性全唾液（UWS）的唾液分泌减少患者比例、症状分布、灼痛严重程度及口腔不适对日常生活的影响（Eff-life）以及阳性症状困扰指数（PSDI）方面存在显著差异。原发性组的UWS流速显著高于继发性组，UWS唾液分泌减少患者比例更低，Eff-life严重程度更低。中间组的灼痛强度和Eff-life显著高于原发性组，PSDI评分更高。原发性组刺激全唾液中的皮质醇和脱氢表雄酮（DHEA）水平显著高于继发性组。
本研究结果表明，临床特征可区分各类型BMS。皮质醇和DHEA水平是区分原发性和继发性BMS的潜在唾液生物标志物。
