立消散治疗原发性灼口综合征的疗效：一项回顾性研究。

Efficacy of rikkosan for primary burning mouth syndrome: a retrospective study.

作者信息

Hato Hiroyuki, Sakata Ken-Ichiro, Sato Jun, Asaka Takuya, Ohga Noritaka, Yamazaki Yutaka, Kitagawa Yoshimasa

机构信息

Department of Oral Diagnosis and Medicine, Faculty of Dental Medicine, Hokkaido University, Kita-13 Nishi-7, Kita-ku, 060-8586, Sapporo, Japan.

Gerodontology, Department of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan.

出版信息

Biopsychosoc Med. 2021 Oct 30;15(1):19. doi: 10.1186/s13030-021-00221-2.

DOI:10.1186/s13030-021-00221-2

PMID:34717696

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8556893/

Abstract

BACKGROUND

Burning mouth syndrome (BMS) is a chronic condition characterized by pain in the oral cavity. Kampo medicine is a traditional Japanese medical system that has its roots partly in ancient Chinese medicine. The purpose of this study is to evaluate the efficacy of rikkosan-a traditional Japanese herbal medicine (Kampo)-in the treatment of primary BMS.

MAIN BODY

A single-center retrospective study was conducted in 32 patients who were diagnosed with primary BMS and treated with rikkosan alone through gargling (2.5 g rikkosan dissolved in 50 mL hot water) three times daily. Patients were asked to evaluate their pain using a numerical rating scale (NRS) at first visit and after 1 month. One patient had stomatitis as a side effect after gargling with rikkosan, however, no side effects were observed in other patients. Overall NRS scores decreased significantly between the first visit (7.6 ± 2.7) and the 1-month visit (5.6 ± 2.8).

CONCLUSIONS

Rikkosan may be an effective treatment for primary BMS.

摘要

背景

灼口综合征（BMS）是一种以口腔疼痛为特征的慢性疾病。汉方医学是一种传统的日本医学体系，其部分根源可追溯到古代中医。本研究的目的是评估日本传统草药制剂历节散（rikkosan）治疗原发性灼口综合征的疗效。

主体

对32例被诊断为原发性灼口综合征且仅通过含漱历节散（2.5克历节散溶解于50毫升热水中）每日三次进行治疗的患者开展了一项单中心回顾性研究。要求患者在初诊时及1个月后使用数字评定量表（NRS）评估其疼痛程度。1例患者在含漱历节散后出现口腔炎这一副作用，不过，其他患者未观察到副作用。初诊时（7.6±2.7）与1个月复诊时（5.6±2.8）的总体NRS评分显著降低。