Goksever Celik Hale, Celik Engin, Uhri Mehmet, Bastu Ercan, Gungor Mete, Buyru Faruk
Obstetrics and Gynecology, Acibadem University, Istanbul, TUR.
Obsterics and Gynecology, Acibadem Atasehir Hospital, Istanbul, TUR.
Cureus. 2024 Mar 16;16(3):e56262. doi: 10.7759/cureus.56262. eCollection 2024 Mar.
The study aimed to evaluate whether there is a difference in the expression of programmed cell death 1 ligand (PD-L1) in the cell lining of endometrioma between cases with and without recurrent disease. Additionally, we sought to assess the effect of cyst size and serum CA125 level on the expression of PD-L1 staining. The pathological specimens were immunohistochemically stained for PD-L1 in women who underwent surgery for endometrioma. All patients were evaluated to confirm if their endometriomas had recurred or not. A total of 36 patients who underwent surgery for endometrioma were included. The study population was divided into two groups according to their recurrence status. The study group (having recurrence) (n=12) and the control group (having no recurrence) (n=24) were compared regarding their demographic and clinical characteristics and PD-L1 staining. PD-L1 staining and the intensity of PD-L1 staining did not differ between the patients with and without recurrence. No variable, including parity, cyst size, serum CA125 level, and PD-L1 staining, was found to be significant in determining recurrence. No significant difference was found between the groups with and without PD-L1 staining in terms of cyst size and serum CA125 level. Although we have shown that PD-L1 expression could not be used for the prediction of recurrence, further studies are needed to assess this issue and to guide the development of new immunotherapeutic agents on this basis.
本研究旨在评估复发性疾病患者与非复发性疾病患者的子宫内膜异位囊肿内衬细胞中程序性细胞死亡1配体（PD-L1）的表达是否存在差异。此外，我们试图评估囊肿大小和血清CA125水平对PD-L1染色表达的影响。对接受子宫内膜异位症手术的女性病理标本进行PD-L1免疫组织化学染色。评估所有患者以确认其子宫内膜异位症是否复发。共有36例接受子宫内膜异位症手术的患者纳入研究。根据复发状态将研究人群分为两组。比较研究组（有复发）（n = 12）和对照组（无复发）（n = 24）的人口统计学和临床特征以及PD-L1染色情况。有复发和无复发患者之间的PD-L1染色及PD-L1染色强度无差异。在确定复发方面，未发现包括产次、囊肿大小、血清CA125水平和PD-L1染色在内的任何变量具有显著性。在囊肿大小和血清CA125水平方面，有PD-L1染色和无PD-L1染色的组之间未发现显著差异。尽管我们已表明PD-L1表达不能用于预测复发，但仍需要进一步研究来评估这一问题，并在此基础上指导新型免疫治疗药物的开发。
