Sotio Biotech, Prague, Czech Republic
Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.
J Immunother Cancer. 2021 Oct;9(10). doi: 10.1136/jitc-2021-002873.
Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive to immune checkpoint inhibitors, correlating with a tumor microenvironment that exhibits poor infiltration by immune cells and active immunosuppression. Here, we comparatively summarize the humoral and cellular features of primary and metastatic EOC, comparatively analyze their impact on disease outcome, and propose measures to alter them in support of treatment sensitivity and superior patient survival.
上皮性卵巢癌 (EOC) 是一种相对罕见的恶性肿瘤，但却是女性癌症相关死亡的第五大主要原因，这主要反映了恶性疾病在早期、诊断前向腹膜的扩散。与其他肿瘤不同，EOC 对免疫检查点抑制剂几乎没有反应，这与肿瘤微环境中免疫细胞浸润不良和活性免疫抑制相关。在这里，我们比较总结了原发性和转移性 EOC 的体液和细胞特征，比较分析了它们对疾病结局的影响，并提出了改变这些特征的措施，以支持治疗敏感性和提高患者生存率。
