Willoughby-Dudley Kathleen Angela, Darwin Marielle L, Davalos Deana B
Department of Psychology, Colorado State University, Fort Collins, CO, USA.
Curr Alzheimer Res. 2024;21(1):3-23. doi: 10.2174/0115672050288199240408035201.
As modern medicine continues to make strides in effective surgical treatments, we must also consider the critical impact of anesthesia on neuropsychological outcomes. Recent evidence suggests that anesthesia exposure may be a risk factor for postoperative cognitive decline and the eventual development of dementia.
To explore the vulnerability of the aging brain in the context of anesthesia exposure in surgery, studies will be reviewed, and pertinent findings will be highlighted and explored to better understand risks and possible factors that need to be considered when contemplating surgery.
A narrative review was conducted using a combination of MEDLINE and APA PsycINFO databases to shed light on themes across studies assessing general trends regarding the influence of anesthesia on postoperative cognitive decline.
A search of relevant literature identified 388 articles. Excluding results outside the parameters of this study, the review includes quality assessments for 24 articles.
While findings are inconclusive, suggestions for further investigation into the relationship between anesthesia exposure and increased risk for postoperative cognitive decline are discussed, in addition to factors that may allow for greater informed disclosure of potential risks of anesthesia in older adults.
随着现代医学在有效的外科治疗方面不断取得进展，我们还必须考虑麻醉对神经心理结果的关键影响。最近的证据表明，麻醉暴露可能是术后认知功能下降以及最终发展为痴呆症的一个风险因素。
为了探讨在手术中麻醉暴露情况下衰老大脑的脆弱性，将对相关研究进行综述，并突出和探讨相关发现，以更好地理解在考虑手术时需要考虑的风险和可能因素。
采用叙述性综述，结合MEDLINE和APA PsycINFO数据库，以阐明评估麻醉对术后认知功能下降影响的总体趋势的各项研究中的主题。
对相关文献的检索共识别出388篇文章。排除本研究参数范围之外的结果后，该综述包括对24篇文章的质量评估。
虽然研究结果尚无定论，但除了可能有助于更充分地向老年人披露麻醉潜在风险的因素外，还讨论了对麻醉暴露与术后认知功能下降风险增加之间关系进行进一步研究的建议。
