Bera Debasish, Sarkar Rajib, Dhar Tiyasa, Saha Pinaki, Ghosh Prasanta, Mukhopadhyay Chhanda
Department of Chemistry, University of Calcutta, 92 APC Road, Kolkata-700009, India.
Department of Chemistry, Prabhu Jagatbandhu College, Jhorehat, Andul-Mouri, Howrah-711302, India.
Org Biomol Chem. 2024 May 8;22(18):3684-3692. doi: 10.1039/d4ob00383g.
Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C-N coupling and C-O coupling under oxidant-free conditions are outlined. This protocol is operationally simple and leads to various functionalized substituted imidazoles or oxazoles in good yields. To date, a very limited number of oxidation protocols have been established, where DMSO acts solely as a catalyst or an oxidant or both. In this report, DMSO is not only used as a C-N/C-O coupling agent but is also used as the oxidant required for these oxidative transformations. Hence, our demonstrated DMSO-promoted catalyst-free coupling transformation has the ability to lead to a new dimension in the field of oxidative coupling.
概述了在无氧化剂条件下二甲基亚砜（DMSO）促进的无催化剂氧化C-N偶联和C-O偶联。该方法操作简单，能以良好的产率得到各种官能化的取代咪唑或恶唑。迄今为止，已建立的氧化方法数量非常有限，其中DMSO仅作为催化剂或氧化剂或两者兼而有之。在本报告中，DMSO不仅用作C-N/C-O偶联剂，还用作这些氧化转化所需的氧化剂。因此，我们所展示的DMSO促进的无催化剂偶联转化有能力在氧化偶联领域开辟一个新的方向。
