Park S W, Ueno R, Hayaishi O
Biochem Int. 1985 Jun;10(6):873-9.
The developmental changes of prostaglandin (PG) synthesizing enzymes in the digestive system (stomach and small intestine) and the immune system (spleen and thymus) of rats were investigated. In all the digestive organs, the predominant PG produced from PGH2 changed at around 2 weeks after birth to another PG. Further, the predominant activities of PG synthesizing enzymes were different organ by organ in the digestive system. In the case of the immune system, only the activity of PGD2 synthesizing enzyme displayed a significant increase during development and the activities of other PG synthesizing enzymes remained insignificant throughout the development. These results suggest that PGs may play important roles during the development of each organ.
研究了大鼠消化系统（胃和小肠）和免疫系统（脾脏和胸腺）中前列腺素（PG）合成酶的发育变化。在所有消化器官中，由PGH2产生的主要PG在出生后约2周时转变为另一种PG。此外，PG合成酶的主要活性在消化系统中因器官而异。在免疫系统中，只有PGD2合成酶的活性在发育过程中显著增加，而其他PG合成酶的活性在整个发育过程中仍不显著。这些结果表明，PGs可能在每个器官的发育过程中发挥重要作用。
