Linton A L, Richmond J M, Clark W F, Lindsay R M, Driedger A A, Lamki L M
Clin Nephrol. 1985 Aug;24(2):84-7.
67Ga scintigraphy was performed in 44 patients with various biopsy proven forms of renal disease and in a further 64 patients, some with clinically diagnosed renal disease and some with non-renal disorders. Renal uptake of gallium at 48 hours was graded by two blinded observers and by tissue ratios determined by computer. All 11 patients with biopsy proven acute drug-induced interstitial nephritis demonstrated intense, diffuse, bilateral renal 67Ga uptake, a phenomenon observed in only five of the other 30 patients with biopsy proven renal disease and in four of the 64 patients with clinical diagnoses only. No patient with acute tubular necrosis demonstrated significant renal gallium uptake. It is suggested that 67Ga scintigraphy is an excellent screening test for the presence of acute interstitial nephritis and helps to identify which patients with unexplained acute renal failure require renal biopsy.
对44例经活检证实患有各种肾病的患者以及另外64例患者进行了67镓闪烁扫描，后者中有些患者患有临床诊断的肾病，有些患有非肾脏疾病。由两名不知情的观察者以及通过计算机测定的组织比率对48小时时肾脏对镓的摄取情况进行分级。所有11例经活检证实为急性药物性间质性肾炎的患者均表现出双侧肾脏对67镓的摄取强烈、弥漫，这种现象仅在另外30例经活检证实患有肾病的患者中的5例以及仅临床诊断的64例患者中的4例中观察到。没有急性肾小管坏死患者表现出明显的肾脏镓摄取。提示67镓闪烁扫描是急性间质性肾炎存在的一项出色的筛查试验，并有助于确定哪些不明原因的急性肾衰竭患者需要进行肾活检。
