Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing, 100124, China.
Department of Imaging and Interventional Radiology, Lady Reading Hospital (LRH-MTI), Peshawar, Pakistan.
Radiol Med. 2024 Jun;129(6):912-924. doi: 10.1007/s11547-024-01814-x. Epub 2024 Apr 16.
To develop a novel magnetic resonance imaging (MRI) phantom for producing F-score (for fat) and W-score (for water) and to evaluate the performance of these scores in assessing osteoporosis and related vertebral fractures.
First, a real-time phantom consisting of oil and water tubes was manufactured. Then, 30 female volunteers (age: 62.3 ± 6.3 years) underwent lumbar spine examination with MRI (using a novel phantom) and dual-energy X-ray absorptiometry (DXA), following ethical approval. MRI phantom-based F-score and W-score were defined by normalizing the vertebral signal intensities (SIs) by the oil and water SIs of the phantom on T1- and T2-weighted images, respectively. The diagnostic performances of the new scores for assessing osteoporosis and vertebral fractures were examined using receiver operating characteristic analysis and compared with DXA-measured areal bone mineral density (DXA-aBMD).
The F-score and W-score were greater in the osteoporotic patients (3.93 and 2.29) than the non-osteoporotic subjects (3.05 and 1.79) and achieved AUC values of 0.85 and 0.74 (p < 0.05), respectively, when detecting osteoporosis. Similarly, F-score and W-score had greater values for the fracture patients (3.94 and 2.53) than the non-fracture subjects (3.14 and 1.69) and produced better AUC values (0.90 for W-score and 0.79 for F-score) compared to DXA-aBMD (AUC: 0.27, p < 0.05). In addition, the F-score and W-score had a strong correlation (r = 0.77; p < 0.001).
A novel real-time lumber spine MRI phantom was developed, based upon which newly defined F-score and W-score were able to detect osteoporosis and demonstrated an improved ability over DXA-aBMD in differentiating patients with vertebral fractures.
开发一种新型磁共振成像（MRI）体模，用于产生 F 分数（用于脂肪）和 W 分数（用于水），并评估这些分数在评估骨质疏松症和相关椎体骨折中的性能。
首先，制造了一个由油和水管组成的实时体模。然后，在获得伦理批准后，对 30 名女性志愿者（年龄：62.3±6.3 岁）进行了腰椎 MRI（使用新型体模）和双能 X 线吸收法（DXA）检查。在 T1 加权和 T2 加权图像上，通过对椎体信号强度（SI）进行归一化，定义了 MRI 体模的 F 分数和 W 分数，分别为油和水的 SI。使用接收者操作特征分析（ROC）评估新分数评估骨质疏松症和椎体骨折的诊断性能，并与 DXA 测量的面积骨矿物质密度（DXA-aBMD）进行比较。
在骨质疏松症患者中，F 分数和 W 分数（3.93 和 2.29）大于非骨质疏松症患者（3.05 和 1.79），并分别获得 0.85 和 0.74 的 AUC 值（p<0.05），用于检测骨质疏松症。同样，在骨折患者中，F 分数和 W 分数（3.94 和 2.53）大于非骨折患者（3.14 和 1.69），并且与 DXA-aBMD 相比，产生了更好的 AUC 值（W 分数为 0.90，F 分数为 0.79）（AUC：0.27，p<0.05）。此外，F 分数和 W 分数之间具有很强的相关性（r=0.77；p<0.001）。
开发了一种新型实时腰椎 MRI 体模，基于该体模，新定义的 F 分数和 W 分数能够检测骨质疏松症，并在区分椎体骨折患者方面表现出优于 DXA-aBMD 的能力。
