Fauchere J L, Berche P, Kreis H, Dandavino R, Descamps J M, Crosnier J
Nouv Presse Med. 1979 Jun 2;8(24):1991-5.
Bacterial infections were studied in 51 immunosuppression kidney transplant recipients. Eighty infectious episodes occured in the first six post-transplantation months. Forty percent of these episodes were nonfebrile, detected during the routine bacteriological follow-up examination. Out of these 80 bacterial infections, 59 were localized (47 in the urinary tract, nine in the surgical wound and three in the lungs) and 21 had spread. Neutopenia occured in 13 patients, in association with septicaemia in eight of them. Usually septicaemia appeared before neutropenia. In 12 cases, infectious episodes (10 septicaemias and two localized infections) and transplant failure were closely related. The bacterial strains responsible for these infections were essentially: Staphylococcus spp (39), Streptococcus spp (14), Klebsiella pneumoniae (9), Escherichia coli (9). Most of the localized infections cleared up when treated with a specific antibiotic. Seven failures of antibiotic treatment were observed in 21 cases of generalized infections. The importance of regular post-transplantation bacteriological check-up in detecting and treating infectious complications in graft recipients must be emphasized.
对51例免疫抑制的肾移植受者的细菌感染情况进行了研究。移植后的前六个月共发生80次感染发作。其中40%的发作无发热症状,是在常规细菌学随访检查中发现的。在这80例细菌感染中,59例为局限性感染(47例发生在泌尿道,9例在手术伤口,3例在肺部),21例已扩散。13例患者出现中性粒细胞减少,其中8例伴有败血症。败血症通常在中性粒细胞减少之前出现。12例中,感染发作(10例败血症和2例局限性感染)与移植失败密切相关。引起这些感染的细菌菌株主要有:葡萄球菌属(39株)、链球菌属(14株)、肺炎克雷伯菌(9株)、大肠杆菌(9株)。大多数局限性感染经特异性抗生素治疗后痊愈。21例全身性感染中有7例抗生素治疗失败。必须强调移植后定期进行细菌学检查对检测和治疗移植受者感染并发症的重要性。