Warwick Evidence, Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Warwick Medical School, University of Warwick, Coventry, United Kingdom.
PLoS One. 2024 Apr 16;19(4):e0301889. doi: 10.1371/journal.pone.0301889. eCollection 2024.
The aim of this paper is to investigate what factors are associated to cardiovascular disease and what differences exists between Asians living in the UK (from the English Longitudinal Study of Ageing) and the Asians living in India (from the Longitudinal Ageing Study in India).
Logistic regression was used to investigate how demographic and physical performance factors were associated with cardiovascular disease using data from Wave 6 of the English Longitudinal Study of Ageing and Wave 1 of the Longitudinal Study of Ageing in India, with the main variable of interest being country of residence, Asians in England or Asians in India.
A total of 83,997 participants were included in the analyses. In the primary analysis, 73,396 participants from LASI were compared to 171 Asians in ELSA. After adjusting for age, blood pressure, resting heart rate, sex, waist circumference, gait, handgrip strength and standing balance, there was a statistically significant difference for the outcome of CVD between Whites ELSA (reference) and the participants of LASI (odds ratio = 0.77; 95% confidence interval = 0.60 to 0.99). There were no significant differences in CVD between the LASI participants, Asian ELSA, and the Non-White but not Asian ELSA groups.
No difference was found between Asians that live in India compared to ethnic minorities living in England, including Asians, after adjusting for confounders, but was found between Whites in ELSA compared to LASI participants. A key limitation was the massive disparity in sample sizes between the ELSA subgroups and LASI. Further work is required where comparable sample sizes and longitudinal analyses allow trends to be identified and to investigate the factors associated with the difference in CVD between two similar ethnicities living in distinct locations.
After adjusting for risk factors, there was no difference in CVD between localised Asians and the ethnic minorities in the UK, but there was a difference between the majority ethnicities in the respective countries.
本文旨在探讨哪些因素与心血管疾病相关，以及居住在英国的亚洲人（来自英国老龄化纵向研究）和居住在印度的亚洲人（来自印度老龄化纵向研究）之间存在哪些差异。
使用英国老龄化纵向研究第 6 波和印度老龄化纵向研究第 1 波的数据，采用逻辑回归分析人口统计学和身体表现因素与心血管疾病的相关性，主要感兴趣的变量是居住国家，即英国的亚洲人或印度的亚洲人。
共有 83997 名参与者纳入分析。在主要分析中，将 LASI 的 73396 名参与者与 ELSA 的 171 名亚洲人进行比较。在调整年龄、血压、静息心率、性别、腰围、步态、握力和站立平衡后，ELSA 的白人（参照组）和 LASI 的参与者之间心血管疾病结局存在统计学显著差异（优势比=0.77；95%置信区间=0.60 至 0.99）。LASI 的参与者、ELSA 的亚洲人以及非白人但非亚洲人 ELSA 组之间在心血管疾病方面无显著差异。
在调整混杂因素后，与居住在英国的少数民族（包括亚洲人）相比，居住在印度的亚洲人之间没有差异，但与 ELSA 的白人相比，LASI 的参与者之间存在差异。一个关键的局限性是 ELSA 亚组和 LASI 之间的样本量差异巨大。需要进一步开展工作，以便在具有可比样本量和纵向分析的情况下，确定趋势并调查导致居住在不同地点的两个相似族群之间心血管疾病差异的相关因素。
在调整风险因素后，居住在英国的亚洲人局部群体与少数民族之间在心血管疾病方面没有差异，但在两国的多数族裔之间存在差异。
