Department of Medicine, The Aga Khan University, Karachi, PK.
Division of Cardiology, Department of Medicine, Duke University, Durham, NC, US.
Glob Heart. 2021 Jan 18;16(1):4. doi: 10.5334/gh.815.
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Health research is crucial to managing disease burden. Previous work has highlighted marked discrepancies in research output and disease burden between high-income countries (HICs) and low- and lower-middle-income countries (LI-LMICs) and there is little data to understand whether this gap has bridged in recent years. We conducted a global, country level bibliometric analysis of CVD publications with respect to trends in disease burden and county development indicators.
A search filter with a precision and recall of 0.92 and 0.91 respectively was developed to extract cardiovascular publications from the Web of Science (WOS) for the years 2008-2017. Data for disease burden and country development indicators were extracted from the Global Burden of Disease and the World Bank database respectively.
Our search revealed 847,708 CVD publications for the period 2008-17, with a 43.4% increase over the decade. HICs contributed 81.1% of the global CVD research output and accounted for 8.1% and 8.5% of global CVD DALY losses deaths respectively. LI-LMICs contributed 2.8% of the total output and accounted for 59.5% and 57.1% global CVD DALY losses and death rates.
A glaring disparity in research output and disease burden persists. While LI-LMICs contribute to the majority of DALYs and mortality from CVD globally, their contribution to research output remains the lowest. These data call on national health budgets and international funding support to allocate funds to strengthen research capacity and translational research to impact CVD burden in LI-LMICs.
心血管疾病（CVD）是全球范围内导致死亡和残疾的主要原因。健康研究对于管理疾病负担至关重要。先前的工作已经强调了高收入国家（HICs）和低收入及中低收入国家（LI-LMICs）之间在研究产出和疾病负担方面存在显著差异，并且几乎没有数据可以了解近年来这一差距是否已经缩小。我们对 CVD 出版物进行了全球、国家级的文献计量分析，以了解疾病负担和国家发展指标的趋势。
开发了一个搜索过滤器，其精度和召回率分别为 0.92 和 0.91，用于从 Web of Science（WOS）中提取 2008-2017 年的心血管出版物。疾病负担和国家发展指标的数据分别从全球疾病负担和世界银行数据库中提取。
我们的搜索结果显示，2008-17 年期间有 847,708 篇 CVD 出版物，十年间增长了 43.4%。HICs 贡献了全球 CVD 研究产出的 81.1%，分别占全球 CVD 残疾调整生命年（DALY）损失死亡的 8.1%和 8.5%。LI-LMICs 贡献了总产出的 2.8%，占全球 CVD DALY 损失和死亡率的 59.5%和 57.1%。
研究产出和疾病负担之间存在明显的差距。虽然 LI-LMICs 对全球 CVD 的 DALYs 和死亡率的贡献最大，但它们对研究产出的贡献仍然最低。这些数据呼吁国家卫生预算和国际资金支持，将资金分配用于加强研究能力和转化研究，以减轻 LI-LMICs 的 CVD 负担。
