Kim Junhyung, Jeong Hyun-Ghang, Lee Moon-Soo, Pae Chi-Un, Patkar Ashwin A, Jeon Sang Won, Shin Cheolmin, Han Changsu
Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Department of Life Sciences, Korea University, Seoul, Korea.
Clin Psychopharmacol Neurosci. 2024 May 31;22(2):253-262. doi: 10.9758/cpn.23.1070. Epub 2023 Sep 6.
While the association between depression and frailty in the elderly population has been investigated, the psychological factors that mediate such a relationship remain unknown. The identification of psychological factors in interventions for depression treatment in the elderly may assist in the treatment and care. We aimed to explore the mediating effects of anger, anxiety, and resilience on the link between frailty and depression symptoms in patients with late-life depression.
A sample of 203 older adults completed questionnaires that assessed depression, anger, resilience, and anxiety. To measure frailty, participants were evaluated using a self-rated health questionnaire, weight-adjusted waist index related to sarcopenia, and weight-adjusted handgrip strength to evaluate weakness. A mediation model was tested, hypothesizing that anger, anxiety, and resilience would partially mediate the strength of the frailty-depression link in the elderly.
Only self-rated health showed a significant association with depressive symptoms in late-life depression. Our study demonstrated that frailty has both direct and indirect associations with depression, mediated by anger, resilience, and anxiety.
Given that anger, resilience, and anxiety influence the link between self-rated health and depression, interventions that lead to increased resilience and decreased anger and anxiety may be promising to reduce depressive symptoms in older adults with depression.
虽然已对老年人群中抑郁与衰弱之间的关联进行了研究，但介导这种关系的心理因素仍不清楚。确定老年抑郁症治疗干预中的心理因素可能有助于治疗和护理。我们旨在探讨愤怒、焦虑和心理弹性对老年期抑郁症患者衰弱与抑郁症状之间联系的中介作用。
203名老年人完成了评估抑郁、愤怒、心理弹性和焦虑的问卷调查。为了测量衰弱，使用自评健康问卷、与肌肉减少症相关的体重调整腰围指数以及体重调整握力来评估参与者的虚弱程度。测试了一个中介模型，假设愤怒、焦虑和心理弹性将部分介导老年人衰弱与抑郁之间联系的强度。
在老年期抑郁症中，只有自评健康与抑郁症状有显著关联。我们的研究表明，衰弱与抑郁既有直接关联，也有通过愤怒、心理弹性和焦虑介导的间接关联。
鉴于愤怒、心理弹性和焦虑会影响自评健康与抑郁之间的联系，能够提高心理弹性并降低愤怒和焦虑的干预措施可能有望减轻老年抑郁症患者的抑郁症状。
