Department of Pediatrics, Division of Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713, GZ, the Netherlands.
Department of Health Sciences, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713, GZ, the Netherlands.
Pediatr Res. 2024 Sep;96(4):1062-1067. doi: 10.1038/s41390-024-03188-2. Epub 2024 Apr 16.
Neurodevelopmental trajectories of preterm children may have changed due to changes in care and in society. We aimed to compare neurodevelopmental trajectories in early and moderately late preterm children, measured using the Developmental (D)-score, in two cohorts born 15 years apart.
We included early preterm and moderately late preterm children from two Dutch cohorts (LOLLIPOP, 2002-2003 and ePREM, 2016-2017). ePREM counterparts were matched to LOLLIPOP participants by gestational age and sex. D-score trajectories were summarized by a multilevel model with random intercepts and random slopes, and multigroup analyses were used to test if the intercepts and slopes differed across cohorts.
We included 1686 preterm children (1071 moderately late preterm, 615 early preterm) from LOLLIPOP, and matched these with 1686 ePREM counterparts. The neurodevelopmental trajectories of the two cohorts were mostly similar. For early preterm children, we found no statistically significant differences. For moderately late preterm children, both the intercept (43.0 vs. 42.3, p < 0.001) and slope (23.5 vs. 23.9, p = 0.002) showed some, but only clinically minor, differences.
Developmental trajectories, measured using the D-score, in the first four years of life are comparable and stable across a period of 15 years for both early and moderately late preterm children.
Neurodevelopmental trajectories are similar for early and moderately late preterm children born 15 years apart and thus seem quite stable in time. The validated Developmental score visualizes these trajectories based on developmental milestone attainment Because of its stability over time, the Developmental score trajectory may aid clinicians in neurodevelopmental assessment of preterm children as this simplifies monitoring and interpretation, similar to a growth chart.
由于护理和社会的变化，早产儿的神经发育轨迹可能已经发生了变化。我们旨在比较两个出生时间相隔 15 年的队列中使用发育（D）评分测量的早期和中度晚期早产儿的神经发育轨迹。
我们纳入了来自两个荷兰队列的早期和中度晚期早产儿（LOLLIPOP，2002-2003 年和 ePREM，2016-2017 年）。ePREM 的对应项根据胎龄和性别与 LOLLIPOP 参与者相匹配。使用具有随机截距和随机斜率的多层模型总结 D 评分轨迹，并使用多组分析来测试截距和斜率是否在队列之间有所不同。
我们纳入了来自 LOPPI-POP 的 1686 名早产儿（1071 名中度晚期早产儿，615 名早期早产儿），并将这些早产儿与 1686 名 ePREM 对应者相匹配。两个队列的神经发育轨迹大多相似。对于早期早产儿，我们没有发现统计学上的显著差异。对于中度晚期早产儿，截距（43.0 与 42.3，p<0.001）和斜率（23.5 与 23.9，p=0.002）均显示出一些差异，但仅在临床上略有差异。
使用 D 评分测量的生命前四年的发育轨迹在早期和中度晚期早产儿中是相似的，并且在 15 年的时间内是稳定的。
出生时间相隔 15 年的早期和中度晚期早产儿的神经发育轨迹相似，因此在时间上似乎相当稳定。经过验证的发育评分根据发育里程碑的实现来可视化这些轨迹。由于其随时间的稳定性，发育评分轨迹可以帮助临床医生对早产儿进行神经发育评估，因为这简化了监测和解释，类似于生长图表。
