Lu Chih-Cherng, Ho Shung-Tai, Hu Oliver Yao-Pu, Hsiong Cheng-Huei, Cheng Yuan-Chen, Hsu Che-Hao, Lin Tso-Chou
Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Department of Anesthesiology, Taipei Veterans General Hospital, National Defense Medical Center, Taipei, Taiwan.
Front Pharmacol. 2024 Apr 2;15:1339690. doi: 10.3389/fphar.2024.1339690. eCollection 2024.
Many respiratory but few arterial blood pharmacokinetics of desflurane uptake and disposition have been investigated. We explored the pharmacokinetic parameters in piglets by comparing inspiratory, end-tidal, arterial blood, and mixed venous blood concentrations of desflurane.
Seven piglets were administered inspiratory 6% desflurane by inhalation over 2 h, followed by a 2-h disposition phase. Inspiratory and end-tidal concentrations were detected using an infrared analyzer. Femoral arterial blood and pulmonary artery mixed venous blood were sampled to determine desflurane concentrations by gas chromatography at 1, 3, 5, 10, 20, 30, 40, 50, 60, 80, 100, and 120 min during each uptake and disposition phase. Respiratory and hemodynamic parameters were measured simultaneously. Body uptake and disposition rates were calculated by multiplying the difference between the arterial and pulmonary artery blood concentrations by the cardiac output.
The rates of desflurane body uptake increased considerably in the initial 5 min (79.8 ml.min) and then declined slowly until 120 min (27.0 ml.min). Similar characteristics of washout were noted during the subsequent disposition phase. Concentration-time curves of end-tidal, arterial, and pulmonary artery blood concentrations fitted well to zero-order input and first-order disposition kinetics. Arterial and pulmonary artery blood concentrations were best fitted using a two-compartment model. After 2 h, only 21.9% of the desflurane administered had been eliminated from the body.
Under a fixed inspiratory concentration, desflurane body uptake in piglets corresponded to constant zero-order infusion, and the 2-h disposition pattern followed first-order kinetics and best fitted to a two-compartment model.
已对许多呼吸过程中地氟烷摄取和处置的情况进行了研究，但动脉血药代动力学方面的研究较少。我们通过比较地氟烷的吸入气、呼气末、动脉血和混合静脉血浓度，探讨了仔猪的药代动力学参数。
7只仔猪通过吸入法给予6%的地氟烷，持续2小时，随后进入2小时的处置阶段。使用红外分析仪检测吸入气和呼气末浓度。在每个摄取和处置阶段的1、3、5、10、20、30、40、50、60、80、100和120分钟时，采集股动脉血和肺动脉混合静脉血，用气相色谱法测定地氟烷浓度。同时测量呼吸和血流动力学参数。通过将动脉血和肺动脉血浓度之差乘以心输出量来计算机体摄取和处置率。
地氟烷机体摄取率在最初5分钟内显著增加（79.8 ml/min），然后缓慢下降，直至120分钟时（27.0 ml/min）。在随后的处置阶段也观察到了类似的清除特征。呼气末、动脉血和肺动脉血浓度的浓度-时间曲线很好地拟合了零级输入和一级处置动力学。动脉血和肺动脉血浓度最好用二室模型拟合。2小时后，给予的地氟烷仅21.9%从体内消除。
在固定的吸入浓度下，仔猪体内地氟烷的摄取相当于恒定的零级输注，2小时的处置模式遵循一级动力学，且最适合二室模型。
