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脆弱的双手:使用 595nm 脉冲染料激光治疗老年手上的非黑素瘤皮肤癌。

Fragile hands: targeting nonmelanoma skin cancer on older hands using 595 nm pulsed dye laser.

机构信息

Heersink School of Medicine, University of Alabama Birmingham, Birmingham, Alabama, United States.

Department of Dermatology, University of Utah, Salt Lake City, Utah, United States.

出版信息

Lasers Med Sci. 2024 Apr 17;39(1):101. doi: 10.1007/s10103-024-04047-6.

DOI:10.1007/s10103-024-04047-6
PMID:38630146
Abstract

PURPOSE

The mainstay of treatment for nonmelanoma skin cancer (NMSC) on thin skin remains surgical, but procedures on older hands may be complicated by skin fragility and dermal atrophy. Used without cooling, 595 nm (nm) pulsed dye laser (PDL) has the capability of destroying NMSC through nonspecific thermal necrosis. The purpose of this study was to understand recurrence of NMSC on dorsal hands of older patients after one or two treatments using 595 nm PDL.

METHODS

A retrospective chart review identified 147 cases of NMSC located on the dorsal hands treated with 595 nm PDL. Cases of basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) were included. All patients received one to two treatments with PDL. The primary outcome was the recurrence of carcinoma.

RESULTS

Among NMSC cases treated with PDL, recurrence occurred in 12 patients (8.2%). No cases of BCC recurred during the study period. Recurrence of SCC was 4.7% for SCC in situ and 10.4% recurrence for invasive SCC (p = 0.34). Among 71 patients treated once, recurrence occurred in 10 patients (14.1%), and among 76 cases treated twice, recurrence occurred in 2 patients (2.6%, p = 0.01).

CONCLUSION

Two treatments of PDL for NMSC on the dorsal hands of older patients was well tolerated, had low recurrence, and seemed more effective than one treatment.

摘要

目的

治疗薄皮肤非黑色素瘤皮肤癌 (NMSC) 的主要方法仍然是手术,但对于老年患者,由于皮肤脆弱和真皮萎缩,手术可能会变得复杂。在不进行冷却的情况下,595nm 脉冲染料激光 (PDL) 有能力通过非特异性热坏死来破坏 NMSC。本研究旨在了解使用 595nm PDL 对老年患者手背 NMSC 进行一次或两次治疗后的复发情况。

方法

回顾性病历分析确定了 147 例位于手背的 NMSC 病例,这些病例均接受了 595nm PDL 治疗。基底细胞癌 (BCC) 和鳞状细胞癌 (SCC) 病例均包括在内。所有患者均接受了一次或两次 PDL 治疗。主要结局是癌症复发。

结果

在接受 PDL 治疗的 NMSC 病例中,有 12 例 (8.2%) 出现复发。在研究期间,没有 BCC 复发的病例。SCC 原位复发率为 4.7%,侵袭性 SCC 复发率为 10.4%(p=0.34)。在接受一次治疗的 71 例患者中,有 10 例(14.1%)出现复发,而在接受两次治疗的 76 例患者中,有 2 例(2.6%)出现复发(p=0.01)。

结论

对于老年患者手背的 NMSC,两次 PDL 治疗耐受性良好,复发率低,似乎比一次治疗更有效。

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Laser Treatment for Non-Melanoma Skin Cancer: A Systematic Review and Meta-Analysis.激光治疗非黑色素瘤皮肤癌:系统评价和荟萃分析。
Am J Clin Dermatol. 2021 Jan;22(1):25-38. doi: 10.1007/s40257-020-00562-8.
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Radiotherapy Does Not Impact Long-term Function Following Resection of Soft-tissue Sarcomas of the Hand.放疗在手软组织肉瘤切除术后并不影响长期功能。
Anticancer Res. 2020 Mar;40(3):1463-1466. doi: 10.21873/anticanres.14089.
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An Analysis of Laser Therapy for the Treatment of Nonmelanoma Skin Cancer.激光治疗非黑色素瘤皮肤癌的分析
Dermatol Surg. 2017 May;43(5):615-624. doi: 10.1097/DSS.0000000000001048.
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Defining recurrence of nonmelanoma skin cancer after Mohs micrographic surgery: Report of the American College of Mohs Surgery Registry and Outcomes Committee.Mohs 显微外科手术后非黑素瘤皮肤癌复发的定义:美国 Mohs 外科学会注册和结果委员会的报告。
J Am Acad Dermatol. 2016 Nov;75(5):1022-1031. doi: 10.1016/j.jaad.2016.06.047. Epub 2016 Aug 18.
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Nonpersistence of basal cell carcinoma after diagnostic shave biopsy: reconstruction when specimen is negative during surgery.诊断性削切活检后基底细胞癌未持续存在:手术时标本为阴性时的重建
Ann Plast Surg. 2015 Jun;74(6):695-8. doi: 10.1097/01.SAP.0000462324.61391.04.
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Consensus for nonmelanoma skin cancer treatment: basal cell carcinoma, including a cost analysis of treatment methods.非黑色素瘤皮肤癌治疗共识:基底细胞癌,包括治疗方法的成本分析。
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