Heslop H, Richards A M, Nicholls M G, Espiner E A, Ikram H, Maslowski A H
N Z Med J. 1985 Sep 11;98(786):739-42.
The hyponatraemic-hypertensive syndrome due to renal ischaemia is presumed to be uncommon. We describe four patients who presented with this syndrome over a period of 21 months. All were women who smoked heavily and had unilateral atherosclerotic renal ischaemia. Hypokalaemia was present in each patient, and in one case resulted in recurrent ventricular tachycardia. All had noted thirst, polyuria, and weight loss. Initiation of treatment with a converting-enzyme inhibitor reduced arterial pressure precipitously in two patients. Removal of the ischaemic kidney, or chronic therapy with a converting-enzyme inhibitor reversed the biochemical abnormalities and the presenting symptoms, and lowered arterial pressure. Detailed studies in two patients before and after treatment confirmed the central role of the renin-angiotensin system in the development of the hyponatraemic-hypertensive syndrome.
肾缺血所致低钠血症-高血压综合征被认为并不常见。我们描述了4例在21个月期间出现该综合征的患者。所有患者均为重度吸烟的女性，患有单侧动脉粥样硬化性肾缺血。每位患者均存在低钾血症，其中1例导致反复发作的室性心动过速。所有患者均有口渴、多尿和体重减轻的症状。两名患者开始使用转换酶抑制剂治疗后动脉压急剧下降。切除缺血肾或使用转换酶抑制剂进行长期治疗可逆转生化异常和现有症状，并降低动脉压。对两名患者治疗前后的详细研究证实了肾素-血管紧张素系统在低钠血症-高血压综合征发生发展中的核心作用。
